The non-coding RNA landscape of plasma cell dyscrasias

E. Morelli, A. Gullà, R. Rocca, C. Federico, L. Raimondi, S. Malvestiti, V. Agosti, M. Rossi, G. Costa, G. Giavaresi, K.A. Azab, A. Cagnetta, M. Cea, P. Tagliaferri, A. Neri, N.C. Munshi, G. Viglietto, P. Tassone, N. Amodio

Research output: Contribution to journalArticlepeer-review

Abstract

Despite substantial advancements have been done in the understanding of the pathogenesis of plasma cell (PC) disorders, these malignancies remain hard-to-treat. The discovery and subsequent characterization of non-coding transcripts, which include several members with diverse length and mode of action, has unraveled novel mechanisms of gene expression regulation often malfunctioning in cancer. Increasing evidence indicates that such non-coding molecules also feature in the pathobiology of PC dyscrasias, where they are endowed with strong therapeutic and/or prognostic potential. In this review, we aim to summarize the most relevant findings on the biological and clinical features of the non-coding RNA landscape of malignant PCs, with major focus on multiple myeloma. The most relevant classes of non-coding RNAs will be examined, along with the mechanisms accounting for their dysregulation and the recent strategies used for their targeting in PC dyscrasias. It is hoped these insights may lead to clinical applications of non-coding RNA molecules as biomarkers or therapeutic targets/agents in the near future.

Original languageEnglish
Article number320
JournalCancers
Volume12
Issue number2
DOIs
Publication statusPublished - 2020

Keywords

  • LncRNA
  • MiRNA
  • Multiple myeloma
  • Non-coding RNA
  • Plasma cell dyscrasia
  • circular ribonucleic acid
  • long untranslated RNA
  • microRNA
  • microRNA 125a
  • microRNA 125b
  • microRNA 155
  • microRNA 15a
  • microRNA 16
  • microRNA 16 1
  • microRNA 17 92
  • microRNA 181a
  • microRNA 181b
  • microRNA 194 2 192
  • microRNA 199a 5p
  • microRNA 203
  • microRNA 21
  • microRNA 214
  • microRNA 215
  • microRNA 215 194 1
  • microRNA 22
  • microRNA 221
  • microRNA 222
  • microRNA 29b
  • microRNA 34a
  • small nucleolar RNA
  • unclassified drug
  • untranslated RNA
  • clinical feature
  • epigenetics
  • gene targeting
  • human
  • intermethod comparison
  • nonhuman
  • pathogenesis
  • plasma cell dyscrasia
  • Review
  • tumor promotion
  • tumor suppressor gene

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