The number of cells and the cell proliferation in intima of various human arteries

Yu V. Bobryshev, V. P. Karagodin, Zh I. Kovalevskaya, V. A. Myasoedova, E. V. Shapyrina, V. I. Salyamov, Yu M. Kargapolova, D. Yu Galaktionova, A. A. Melnichenko, A. N. Orekhov

Research output: Contribution to journalArticlepeer-review


Increased cell proliferation at the early stages of an atherosclerotic lesion is considered an important stage of development of this pathology, but the degree of the proliferation at various stages of formation of atherosclerotic plaque in various human large arteries so far has been studied insufficiently. In the present work, we studied the thickness of intima and proliferation of the newly "infiltrated" hematogenic and resident cells in atherosclerotic lesion of carotid and coronary arteries; a comparison is also made with similar results obtained on the aorta and presented in our earlier publications. Analysis of thickness of intima and of proliferation in normal intima and at various stages of atherosclerotic lesion (initial stages, lipid strips, lipofibrous plaques, fibrous plaques) showed that, in spite of similar tendencies toward changing the level of infiltration of hematogenic cells and proliferation in various types of arteries, there exist significant quantitative differences between various types of arteries. Thus, it is found that hematogenic cells in lipofibrous plaques of coronary and carotid arteries account for one-third and almost half of the total cell population, respectively, whereas the atherosclerosis-lesioned sites of the aorta, as we showed earlier, contain no more than 15% of hematogenic cells. This allows one to think that the contribution of hemopoietic cells to development of atherosclerosis in carotid and coronary arteries is greater than in the aorta. In spite of differences in the number of the hemopoietic cells accumulating in intima, an analogous bell-shaped dependence of the number of cells on the type of lesion (in the sequence normal intima-initial stages of pathology-lipid strips-lipofibrous plaques-fibrous plaques) was shown for coronary and carotid arteries. Visualization of proliferating (PCNA-positive) cells in atherosclerosed and normal (unchanged) zones of coronary and carotid arteries revealed a similar picture. The maximum number of PCNA-positive resident cells was found in lipofibrous plaques. Changes of the total number of cells were accompanied by a change in the number of proliferating resident and proliferating hematogenic cells.

Original languageEnglish
Pages (from-to)29-39
Number of pages11
JournalCell and Tissue Biology
Issue number1
Publication statusPublished - Feb 2012


  • aorta
  • atherosclerosis
  • carotid artery
  • coronary artery
  • hematogenic cells
  • inflammation
  • proliferation

ASJC Scopus subject areas

  • Cell Biology


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