The occurrence of cholangitis after percutaneous biliary drainage: Evaluation of some risk factors

R. A. Audisio, F. Bozzetti, A. Severini, L. Bellegotti, M. Bellomi, G. Cozzi, P. Pisani, L. Callegari, R. Doci, L. Gennari

Research output: Contribution to journalArticlepeer-review


Sepsis of the biliary tract is often reported after percutaneous transhepatic biliary drainage (PTBD) and is considered a life-threatening condition. The authors studied 39 patients with biliary stenosis (35 with neoplastic stricture and four with benign disease) with the purpose of identifying some factors possibly associated with a higher risk of cholangitis. None of the patients complained of biliary sepsis at the first clinical examination. Several factors were taken into account and were statistically tested according to Miettinen rate ratios to differentiate patients in whom cholangitis would consequently develop: nature, site and extent of basic disease, type and functioning of PTBD, skin contamination and puncture site of PTBD, and bile contamination at PTBD and at follow-up. The presence of bacteria in the first bile (31.5%) was not related to a higher risk. All subjects showed bile contamination after PTBD, but cholangitis developed in only 15 patients, and it was always supported by enteric microorganisms. When we compared patients with cholangitis and subjects without infection, it was possible to demonstrate a statistically significant association of cholangitis and the following: nature of the stricture, presence of multiple intrahepatic biliary obstruction, neoplastic invasion or compression on the duodenum, and presence of Staphylococcus aureus on the skin at puncture site at drainage.

Original languageEnglish
Pages (from-to)507-512
Number of pages6
Issue number5
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Surgery


Dive into the research topics of 'The occurrence of cholangitis after percutaneous biliary drainage: Evaluation of some risk factors'. Together they form a unique fingerprint.

Cite this