The OMERACT ultrasound group: A report from the OMERACT 2016 meeting and perspectives

Lene Terslev, Annamaria Iagnocco, George A.W. Bruyn, Esperanza Naredo, Jelena Vojinovic, Paz Collado, Nemanja Damjanov, Andrew Filer, Georgios Filippou, Stephanie Finzel, Frederique Gandjbakhch, Kei Ikeda, Helen I. Keen, Marion C. Kortekaas, Silvia Magni-Manzoni, Sarah Ohrndorf, Carlos Pineda, Viviana Ravagnani, Bethan Richards, Ilfita SahbudinWolfgang A. Schmidt, Heidi J. Siddle, Maria S. Stoenoiu, Marcin Szkudlarek, Nikolay Tzaribachev, Maria Antonietta D'Agostino

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: To provide an update from the Outcome Measures in Rheumatology (OMERACT) Ultrasound Working Group on the progress for defining ultrasound (US) minimal disease activity threshold at joint level in rheumatoid arthritis (RA) and for standardization of US application in juvenile idiopathic arthritis (JIA). Methods: For minimal disease activity, healthy controls (HC) and patients with early arthritis (EA) who were naive to disease-modifying antirheumatic drugs were recruited from 2 centers. US was performed of the hands and feet, and scored semiquantitatively (0-3) for synovial hypertrophy (SH) and power Doppler (PD). Synovial effusion (SE) was scored a binary variable. For JIA, a Delphi approach and subsequent validation in static images and patient-based exercises were used to developed preliminary definitions for synovitis and a scoring system. Results: For minimal disease activity, 7% HC had at least 1 joint abnormality versus 30% in the EA group. In HC, the findings of SH and PD were predominantly grade 1 whereas all grades were seen in the EA cohort, but SE was rare. In JIA, synovitis can be diagnosed based on B-mode findings alone because of the presence of physiological vascularization. A semiquantitative scoring system (0-3) for synovitis for both B-mode and Doppler were developed in which the cutoff between Doppler grade 2 and grade 3 was 30%. Conclusion: The first step has been taken to define the threshold for minimal disease activity in RA by US and to define and develop a scoring system for synovitis in JIA. Further steps are planned for the continuous validation of US in these areas. The Journal of Rheumatology

Original languageEnglish
Pages (from-to)1740-1743
Number of pages4
JournalJournal of Rheumatology
Volume44
Issue number11
DOIs
Publication statusPublished - Nov 1 2017

Fingerprint

Synovitis
Juvenile Arthritis
Arthritis
Rheumatology
Rheumatoid Arthritis
Joints
Antirheumatic Agents
Foot
Hand
Outcome Assessment (Health Care)
Exercise

Keywords

  • Juvenile idiopathic arthritis
  • Omeract
  • Rheumatoid arthritis ultrasonography

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Terslev, L., Iagnocco, A., Bruyn, G. A. W., Naredo, E., Vojinovic, J., Collado, P., ... D'Agostino, M. A. (2017). The OMERACT ultrasound group: A report from the OMERACT 2016 meeting and perspectives. Journal of Rheumatology, 44(11), 1740-1743. https://doi.org/10.3899/jrheum.161240

The OMERACT ultrasound group : A report from the OMERACT 2016 meeting and perspectives. / Terslev, Lene; Iagnocco, Annamaria; Bruyn, George A.W.; Naredo, Esperanza; Vojinovic, Jelena; Collado, Paz; Damjanov, Nemanja; Filer, Andrew; Filippou, Georgios; Finzel, Stephanie; Gandjbakhch, Frederique; Ikeda, Kei; Keen, Helen I.; Kortekaas, Marion C.; Magni-Manzoni, Silvia; Ohrndorf, Sarah; Pineda, Carlos; Ravagnani, Viviana; Richards, Bethan; Sahbudin, Ilfita; Schmidt, Wolfgang A.; Siddle, Heidi J.; Stoenoiu, Maria S.; Szkudlarek, Marcin; Tzaribachev, Nikolay; D'Agostino, Maria Antonietta.

In: Journal of Rheumatology, Vol. 44, No. 11, 01.11.2017, p. 1740-1743.

Research output: Contribution to journalArticle

Terslev, L, Iagnocco, A, Bruyn, GAW, Naredo, E, Vojinovic, J, Collado, P, Damjanov, N, Filer, A, Filippou, G, Finzel, S, Gandjbakhch, F, Ikeda, K, Keen, HI, Kortekaas, MC, Magni-Manzoni, S, Ohrndorf, S, Pineda, C, Ravagnani, V, Richards, B, Sahbudin, I, Schmidt, WA, Siddle, HJ, Stoenoiu, MS, Szkudlarek, M, Tzaribachev, N & D'Agostino, MA 2017, 'The OMERACT ultrasound group: A report from the OMERACT 2016 meeting and perspectives', Journal of Rheumatology, vol. 44, no. 11, pp. 1740-1743. https://doi.org/10.3899/jrheum.161240
Terslev L, Iagnocco A, Bruyn GAW, Naredo E, Vojinovic J, Collado P et al. The OMERACT ultrasound group: A report from the OMERACT 2016 meeting and perspectives. Journal of Rheumatology. 2017 Nov 1;44(11):1740-1743. https://doi.org/10.3899/jrheum.161240
Terslev, Lene ; Iagnocco, Annamaria ; Bruyn, George A.W. ; Naredo, Esperanza ; Vojinovic, Jelena ; Collado, Paz ; Damjanov, Nemanja ; Filer, Andrew ; Filippou, Georgios ; Finzel, Stephanie ; Gandjbakhch, Frederique ; Ikeda, Kei ; Keen, Helen I. ; Kortekaas, Marion C. ; Magni-Manzoni, Silvia ; Ohrndorf, Sarah ; Pineda, Carlos ; Ravagnani, Viviana ; Richards, Bethan ; Sahbudin, Ilfita ; Schmidt, Wolfgang A. ; Siddle, Heidi J. ; Stoenoiu, Maria S. ; Szkudlarek, Marcin ; Tzaribachev, Nikolay ; D'Agostino, Maria Antonietta. / The OMERACT ultrasound group : A report from the OMERACT 2016 meeting and perspectives. In: Journal of Rheumatology. 2017 ; Vol. 44, No. 11. pp. 1740-1743.
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abstract = "Objective: To provide an update from the Outcome Measures in Rheumatology (OMERACT) Ultrasound Working Group on the progress for defining ultrasound (US) minimal disease activity threshold at joint level in rheumatoid arthritis (RA) and for standardization of US application in juvenile idiopathic arthritis (JIA). Methods: For minimal disease activity, healthy controls (HC) and patients with early arthritis (EA) who were naive to disease-modifying antirheumatic drugs were recruited from 2 centers. US was performed of the hands and feet, and scored semiquantitatively (0-3) for synovial hypertrophy (SH) and power Doppler (PD). Synovial effusion (SE) was scored a binary variable. For JIA, a Delphi approach and subsequent validation in static images and patient-based exercises were used to developed preliminary definitions for synovitis and a scoring system. Results: For minimal disease activity, 7{\%} HC had at least 1 joint abnormality versus 30{\%} in the EA group. In HC, the findings of SH and PD were predominantly grade 1 whereas all grades were seen in the EA cohort, but SE was rare. In JIA, synovitis can be diagnosed based on B-mode findings alone because of the presence of physiological vascularization. A semiquantitative scoring system (0-3) for synovitis for both B-mode and Doppler were developed in which the cutoff between Doppler grade 2 and grade 3 was 30{\%}. Conclusion: The first step has been taken to define the threshold for minimal disease activity in RA by US and to define and develop a scoring system for synovitis in JIA. Further steps are planned for the continuous validation of US in these areas. The Journal of Rheumatology",
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AU - Terslev, Lene

AU - Iagnocco, Annamaria

AU - Bruyn, George A.W.

AU - Naredo, Esperanza

AU - Vojinovic, Jelena

AU - Collado, Paz

AU - Damjanov, Nemanja

AU - Filer, Andrew

AU - Filippou, Georgios

AU - Finzel, Stephanie

AU - Gandjbakhch, Frederique

AU - Ikeda, Kei

AU - Keen, Helen I.

AU - Kortekaas, Marion C.

AU - Magni-Manzoni, Silvia

AU - Ohrndorf, Sarah

AU - Pineda, Carlos

AU - Ravagnani, Viviana

AU - Richards, Bethan

AU - Sahbudin, Ilfita

AU - Schmidt, Wolfgang A.

AU - Siddle, Heidi J.

AU - Stoenoiu, Maria S.

AU - Szkudlarek, Marcin

AU - Tzaribachev, Nikolay

AU - D'Agostino, Maria Antonietta

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N2 - Objective: To provide an update from the Outcome Measures in Rheumatology (OMERACT) Ultrasound Working Group on the progress for defining ultrasound (US) minimal disease activity threshold at joint level in rheumatoid arthritis (RA) and for standardization of US application in juvenile idiopathic arthritis (JIA). Methods: For minimal disease activity, healthy controls (HC) and patients with early arthritis (EA) who were naive to disease-modifying antirheumatic drugs were recruited from 2 centers. US was performed of the hands and feet, and scored semiquantitatively (0-3) for synovial hypertrophy (SH) and power Doppler (PD). Synovial effusion (SE) was scored a binary variable. For JIA, a Delphi approach and subsequent validation in static images and patient-based exercises were used to developed preliminary definitions for synovitis and a scoring system. Results: For minimal disease activity, 7% HC had at least 1 joint abnormality versus 30% in the EA group. In HC, the findings of SH and PD were predominantly grade 1 whereas all grades were seen in the EA cohort, but SE was rare. In JIA, synovitis can be diagnosed based on B-mode findings alone because of the presence of physiological vascularization. A semiquantitative scoring system (0-3) for synovitis for both B-mode and Doppler were developed in which the cutoff between Doppler grade 2 and grade 3 was 30%. Conclusion: The first step has been taken to define the threshold for minimal disease activity in RA by US and to define and develop a scoring system for synovitis in JIA. Further steps are planned for the continuous validation of US in these areas. The Journal of Rheumatology

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