The oncologic role of local treatment in primary metastatic prostate cancer

Pirus Ghadjar, Alberto Briganti, Peter J L De Visschere, Jurgen J. Fütterer, Gianluca Giannarini, Hendrik Isbarn, Piet Ost, Prasanna Sooriakumaran, Christian I. Surcel, Roderick C N van den Bergh, Inge M. van Oort, Ofer Yossepowitch, Guillaume Ploussard

Research output: Contribution to journalArticle

Abstract

Purpose: To determine the oncologic benefit or otherwise of local treatment of the prostate in patients with primary metastatic prostate cancer. Methods: A review of the literature was performed in April 2014 using the Medline/PubMed database. Studies were identified using the search terms “prostate cancer,” “metastatic,” “metastasis,” “high risk,” “radiation therapy,” “radiotherapy” and “prostatectomy” from 1990 until April, 2014. Articles were also identified through searches of references of these articles. Results: Retrospective series and population-based data suggest that the use of local treatment of the prostate in patients with primary metastatic prostate cancer may improve cancer-specific survival and overall survival compared with treating these patients with androgen deprivation therapy alone. The clinical outcome in metastatic prostate cancer is largely determined by the extent of lymph node involvement and overall metastatic burden. Contemporary data are lacking to recommend one alternative of local therapy (radiotherapy or radical prostatectomy) over the other. The primary limitation of this literature review is the lack of published randomized trial assessing the role of local treatment in addition to systemic therapy. Conclusions: Local treatment appears to improve oncologic outcomes in metastatic prostate cancer patients. Nevertheless, due to the lack of high-quality evidence, its role needs to be confirmed in future prospective trials. The selection of ideal candidates and optimal treatment alternative (radiotherapy, radical prostatectomy or other) warrants further investigation.

Original languageEnglish
Pages (from-to)755-761
Number of pages7
JournalWorld Journal of Urology
Volume33
Issue number6
DOIs
Publication statusPublished - Jul 5 2014

Fingerprint

Prostatic Neoplasms
Radiotherapy
Prostatectomy
Therapeutics
Prostate
Survival
Complementary Therapies
PubMed
Androgens
Lymph Nodes
Databases
Neoplasm Metastasis
Population
Neoplasms

Keywords

  • High risk
  • Local treatment
  • Metastasis
  • Metastatic
  • Outcomes
  • Prostate cancer
  • Radiation therapy
  • Radical prostatectomy
  • Radiotherapy

ASJC Scopus subject areas

  • Urology

Cite this

Ghadjar, P., Briganti, A., De Visschere, P. J. L., Fütterer, J. J., Giannarini, G., Isbarn, H., ... Ploussard, G. (2014). The oncologic role of local treatment in primary metastatic prostate cancer. World Journal of Urology, 33(6), 755-761. https://doi.org/10.1007/s00345-014-1347-9

The oncologic role of local treatment in primary metastatic prostate cancer. / Ghadjar, Pirus; Briganti, Alberto; De Visschere, Peter J L; Fütterer, Jurgen J.; Giannarini, Gianluca; Isbarn, Hendrik; Ost, Piet; Sooriakumaran, Prasanna; Surcel, Christian I.; van den Bergh, Roderick C N; van Oort, Inge M.; Yossepowitch, Ofer; Ploussard, Guillaume.

In: World Journal of Urology, Vol. 33, No. 6, 05.07.2014, p. 755-761.

Research output: Contribution to journalArticle

Ghadjar, P, Briganti, A, De Visschere, PJL, Fütterer, JJ, Giannarini, G, Isbarn, H, Ost, P, Sooriakumaran, P, Surcel, CI, van den Bergh, RCN, van Oort, IM, Yossepowitch, O & Ploussard, G 2014, 'The oncologic role of local treatment in primary metastatic prostate cancer', World Journal of Urology, vol. 33, no. 6, pp. 755-761. https://doi.org/10.1007/s00345-014-1347-9
Ghadjar P, Briganti A, De Visschere PJL, Fütterer JJ, Giannarini G, Isbarn H et al. The oncologic role of local treatment in primary metastatic prostate cancer. World Journal of Urology. 2014 Jul 5;33(6):755-761. https://doi.org/10.1007/s00345-014-1347-9
Ghadjar, Pirus ; Briganti, Alberto ; De Visschere, Peter J L ; Fütterer, Jurgen J. ; Giannarini, Gianluca ; Isbarn, Hendrik ; Ost, Piet ; Sooriakumaran, Prasanna ; Surcel, Christian I. ; van den Bergh, Roderick C N ; van Oort, Inge M. ; Yossepowitch, Ofer ; Ploussard, Guillaume. / The oncologic role of local treatment in primary metastatic prostate cancer. In: World Journal of Urology. 2014 ; Vol. 33, No. 6. pp. 755-761.
@article{33ffddda15434e738cbea1ee8cdca8da,
title = "The oncologic role of local treatment in primary metastatic prostate cancer",
abstract = "Purpose: To determine the oncologic benefit or otherwise of local treatment of the prostate in patients with primary metastatic prostate cancer. Methods: A review of the literature was performed in April 2014 using the Medline/PubMed database. Studies were identified using the search terms “prostate cancer,” “metastatic,” “metastasis,” “high risk,” “radiation therapy,” “radiotherapy” and “prostatectomy” from 1990 until April, 2014. Articles were also identified through searches of references of these articles. Results: Retrospective series and population-based data suggest that the use of local treatment of the prostate in patients with primary metastatic prostate cancer may improve cancer-specific survival and overall survival compared with treating these patients with androgen deprivation therapy alone. The clinical outcome in metastatic prostate cancer is largely determined by the extent of lymph node involvement and overall metastatic burden. Contemporary data are lacking to recommend one alternative of local therapy (radiotherapy or radical prostatectomy) over the other. The primary limitation of this literature review is the lack of published randomized trial assessing the role of local treatment in addition to systemic therapy. Conclusions: Local treatment appears to improve oncologic outcomes in metastatic prostate cancer patients. Nevertheless, due to the lack of high-quality evidence, its role needs to be confirmed in future prospective trials. The selection of ideal candidates and optimal treatment alternative (radiotherapy, radical prostatectomy or other) warrants further investigation.",
keywords = "High risk, Local treatment, Metastasis, Metastatic, Outcomes, Prostate cancer, Radiation therapy, Radical prostatectomy, Radiotherapy",
author = "Pirus Ghadjar and Alberto Briganti and {De Visschere}, {Peter J L} and F{\"u}tterer, {Jurgen J.} and Gianluca Giannarini and Hendrik Isbarn and Piet Ost and Prasanna Sooriakumaran and Surcel, {Christian I.} and {van den Bergh}, {Roderick C N} and {van Oort}, {Inge M.} and Ofer Yossepowitch and Guillaume Ploussard",
year = "2014",
month = "7",
day = "5",
doi = "10.1007/s00345-014-1347-9",
language = "English",
volume = "33",
pages = "755--761",
journal = "World Journal of Urology",
issn = "0724-4983",
publisher = "Springer Verlag",
number = "6",

}

TY - JOUR

T1 - The oncologic role of local treatment in primary metastatic prostate cancer

AU - Ghadjar, Pirus

AU - Briganti, Alberto

AU - De Visschere, Peter J L

AU - Fütterer, Jurgen J.

AU - Giannarini, Gianluca

AU - Isbarn, Hendrik

AU - Ost, Piet

AU - Sooriakumaran, Prasanna

AU - Surcel, Christian I.

AU - van den Bergh, Roderick C N

AU - van Oort, Inge M.

AU - Yossepowitch, Ofer

AU - Ploussard, Guillaume

PY - 2014/7/5

Y1 - 2014/7/5

N2 - Purpose: To determine the oncologic benefit or otherwise of local treatment of the prostate in patients with primary metastatic prostate cancer. Methods: A review of the literature was performed in April 2014 using the Medline/PubMed database. Studies were identified using the search terms “prostate cancer,” “metastatic,” “metastasis,” “high risk,” “radiation therapy,” “radiotherapy” and “prostatectomy” from 1990 until April, 2014. Articles were also identified through searches of references of these articles. Results: Retrospective series and population-based data suggest that the use of local treatment of the prostate in patients with primary metastatic prostate cancer may improve cancer-specific survival and overall survival compared with treating these patients with androgen deprivation therapy alone. The clinical outcome in metastatic prostate cancer is largely determined by the extent of lymph node involvement and overall metastatic burden. Contemporary data are lacking to recommend one alternative of local therapy (radiotherapy or radical prostatectomy) over the other. The primary limitation of this literature review is the lack of published randomized trial assessing the role of local treatment in addition to systemic therapy. Conclusions: Local treatment appears to improve oncologic outcomes in metastatic prostate cancer patients. Nevertheless, due to the lack of high-quality evidence, its role needs to be confirmed in future prospective trials. The selection of ideal candidates and optimal treatment alternative (radiotherapy, radical prostatectomy or other) warrants further investigation.

AB - Purpose: To determine the oncologic benefit or otherwise of local treatment of the prostate in patients with primary metastatic prostate cancer. Methods: A review of the literature was performed in April 2014 using the Medline/PubMed database. Studies were identified using the search terms “prostate cancer,” “metastatic,” “metastasis,” “high risk,” “radiation therapy,” “radiotherapy” and “prostatectomy” from 1990 until April, 2014. Articles were also identified through searches of references of these articles. Results: Retrospective series and population-based data suggest that the use of local treatment of the prostate in patients with primary metastatic prostate cancer may improve cancer-specific survival and overall survival compared with treating these patients with androgen deprivation therapy alone. The clinical outcome in metastatic prostate cancer is largely determined by the extent of lymph node involvement and overall metastatic burden. Contemporary data are lacking to recommend one alternative of local therapy (radiotherapy or radical prostatectomy) over the other. The primary limitation of this literature review is the lack of published randomized trial assessing the role of local treatment in addition to systemic therapy. Conclusions: Local treatment appears to improve oncologic outcomes in metastatic prostate cancer patients. Nevertheless, due to the lack of high-quality evidence, its role needs to be confirmed in future prospective trials. The selection of ideal candidates and optimal treatment alternative (radiotherapy, radical prostatectomy or other) warrants further investigation.

KW - High risk

KW - Local treatment

KW - Metastasis

KW - Metastatic

KW - Outcomes

KW - Prostate cancer

KW - Radiation therapy

KW - Radical prostatectomy

KW - Radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=84922659695&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922659695&partnerID=8YFLogxK

U2 - 10.1007/s00345-014-1347-9

DO - 10.1007/s00345-014-1347-9

M3 - Article

C2 - 24997127

AN - SCOPUS:84922659695

VL - 33

SP - 755

EP - 761

JO - World Journal of Urology

JF - World Journal of Urology

SN - 0724-4983

IS - 6

ER -