The ontogenesis of Fcγ receptors and complement receptors CR1 in human peripheral nerve

C. A. Vedeler, E. Scarpini, S. Beretta, R. Doronzo, R. Matre

Research output: Contribution to journalArticlepeer-review


The ontogenesis of Fcγ receptors (FcR) and C3b/C4b receptors (CR1) was studied in peripheral nerves from ten fetuses aged from 20 to 38 weeks using immunohistochemical and functional assays. Monoclonal antibodies (mAbs) against FcR and CR1 stained nerve fibers at 10 weeks of gestation and the staining intensity increased during nerve maturation. FcR and CR1 are probably expressed on Schwann cells and are early markers during the development of peripheral nerves. Functional FcR activity was detected in nerve sections before initiation of myelination, which occurs at approximately 18-19 weeks, whereas functional CR1 activity was found in the sections after myelination. Functional CR1 activity may, therefore, be related to myelin. The ontogenesis of FcR and CR1 was also studied on Schwann cells in culture from three fetuses aged 14, 16 and 19 weeks, using immunofluorescence technique with mAbs. The FcR and CR1 are lost on cultured Schwann cells. This suggests that the receptors are not intrinsic to the cells or that Schwann cells require axonal contact for the expression of FcR and CR1.

Original languageEnglish
Pages (from-to)35-40
Number of pages6
JournalActa Neuropathologica
Issue number1
Publication statusPublished - May 1990


  • C3b/C4b receptor
  • Fcγ receptor
  • Fetal nerve

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology


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