The ontogeny, structure and function of the human T lymphocyte receptor for antigen and major histocompatibility complex.

E. L. Reinherz, H. D. Royer, T. J. Campen, D. Ramarli, M. Fabbi, O. Acuto

Research output: Contribution to journalArticle

Abstract

Recent studies using cloned antigen-specific T lymphocytes and monoclonal antibodies directed at their various surface glycoprotein components have led to identification of the human T cell antigen receptor as a surface complex comprised of a clonotypic 90 kDa Ti heterodimer and the invariant 20 and 25 kDa T3 molecules. Approximately 30,000-40,000 Ti and T3 molecules exist on the surface of human T lymphocytes. These glycoproteins are acquired and expressed during late thymic ontogeny, thus providing the structural basis for immunological competence. The alpha and beta subunits of Ti bear no precursor-product relationship to one another and are encoded by separate germline V, D, J and C segments which rearrange during intrathymic differentiation to form an active gene set. Triggering of the T3-Ti receptor complex induces a rapid increase in free cytoplasmic Ca2+ and gives rise to specific antigen-induced proliferation through an autocrine pathway involving endogenous interleukin-2 production, release and subsequent binding to interleukin-2 receptors. The implications of these findings for understanding of human T cell growth and its regulation in disease states are discussed.

Original languageEnglish
Pages (from-to)211-232
Number of pages22
JournalBiochemical Society Symposia
Volume51
Publication statusPublished - 1986

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Antigen Receptors
T-cells
Major Histocompatibility Complex
T-Lymphocytes
Immunocompetence
Antigens
Dilatation and Curettage
Thyroid Hormone Receptors
Forensic Anthropology
Molecules
Interleukin-2 Receptors
Membrane Glycoproteins
Cell growth
T-Cell Antigen Receptor
Interleukin-2
Glycoproteins
Genes
Monoclonal Antibodies
Growth

ASJC Scopus subject areas

  • Biochemistry

Cite this

The ontogeny, structure and function of the human T lymphocyte receptor for antigen and major histocompatibility complex. / Reinherz, E. L.; Royer, H. D.; Campen, T. J.; Ramarli, D.; Fabbi, M.; Acuto, O.

In: Biochemical Society Symposia, Vol. 51, 1986, p. 211-232.

Research output: Contribution to journalArticle

Reinherz, E. L. ; Royer, H. D. ; Campen, T. J. ; Ramarli, D. ; Fabbi, M. ; Acuto, O. / The ontogeny, structure and function of the human T lymphocyte receptor for antigen and major histocompatibility complex. In: Biochemical Society Symposia. 1986 ; Vol. 51. pp. 211-232.
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