The opioid κ-selective compound U-50, 488H does not inhibit intestinal propulsion in rats

A. Tavani; M. C. Gambino; P. Petrillo

The opioid κ-selective compound U-50, 488H does not inhibit intestinal propulsion in rats

A. Tavani, M. C. Gambino, P. Petrillo

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

The selective κ-compound U-50,488H, at doses producing strong central pharmacological effects (0.5-32 mg kg^-1 i.p.) did not delay the intestinal transit of a charcoal meal and had little or no antagonist action against morphine-induced constipation. It appears that κ-opioid receptors are probably not involved in the mechanisms responsible for opioid-induced constipation.

Original language	English
Pages (from-to)	343-344
Number of pages	2
Journal	Journal of Pharmacy and Pharmacology
Volume	36
Issue number	5
Publication status	Published - 1984

ASJC Scopus subject areas

Pharmaceutical Science
Pharmacology

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title = "The opioid κ-selective compound U-50, 488H does not inhibit intestinal propulsion in rats",

abstract = "The selective κ-compound U-50,488H, at doses producing strong central pharmacological effects (0.5-32 mg kg-1 i.p.) did not delay the intestinal transit of a charcoal meal and had little or no antagonist action against morphine-induced constipation. It appears that κ-opioid receptors are probably not involved in the mechanisms responsible for opioid-induced constipation.",

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AB - The selective κ-compound U-50,488H, at doses producing strong central pharmacological effects (0.5-32 mg kg-1 i.p.) did not delay the intestinal transit of a charcoal meal and had little or no antagonist action against morphine-induced constipation. It appears that κ-opioid receptors are probably not involved in the mechanisms responsible for opioid-induced constipation.

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