The opioid κ-selective compound U-50, 488H does not inhibit intestinal propulsion in rats

A. Tavani, M. C. Gambino, P. Petrillo

Research output: Contribution to journalArticle

Abstract

The selective κ-compound U-50,488H, at doses producing strong central pharmacological effects (0.5-32 mg kg-1 i.p.) did not delay the intestinal transit of a charcoal meal and had little or no antagonist action against morphine-induced constipation. It appears that κ-opioid receptors are probably not involved in the mechanisms responsible for opioid-induced constipation.

Original languageEnglish
Pages (from-to)343-344
Number of pages2
JournalJournal of Pharmacy and Pharmacology
Volume36
Issue number5
Publication statusPublished - 1984

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(trans)-Isomer 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide
Constipation
Opioid Analgesics
Charcoal
Opioid Receptors
Morphine
Meals
Pharmacology

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

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The opioid κ-selective compound U-50, 488H does not inhibit intestinal propulsion in rats. / Tavani, A.; Gambino, M. C.; Petrillo, P.

In: Journal of Pharmacy and Pharmacology, Vol. 36, No. 5, 1984, p. 343-344.

Research output: Contribution to journalArticle

Tavani, A. ; Gambino, M. C. ; Petrillo, P. / The opioid κ-selective compound U-50, 488H does not inhibit intestinal propulsion in rats. In: Journal of Pharmacy and Pharmacology. 1984 ; Vol. 36, No. 5. pp. 343-344.
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