The opioid κ-selective compound U-50, 488H does not inhibit intestinal propulsion in rats

A. Tavani, M. C. Gambino, P. Petrillo

Research output: Contribution to journalArticlepeer-review

Abstract

The selective κ-compound U-50,488H, at doses producing strong central pharmacological effects (0.5-32 mg kg-1 i.p.) did not delay the intestinal transit of a charcoal meal and had little or no antagonist action against morphine-induced constipation. It appears that κ-opioid receptors are probably not involved in the mechanisms responsible for opioid-induced constipation.

Original languageEnglish
Pages (from-to)343-344
Number of pages2
JournalJournal of Pharmacy and Pharmacology
Volume36
Issue number5
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

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