Abstract
The selective κ-compound U-50,488H, at doses producing strong central pharmacological effects (0.5-32 mg kg-1 i.p.) did not delay the intestinal transit of a charcoal meal and had little or no antagonist action against morphine-induced constipation. It appears that κ-opioid receptors are probably not involved in the mechanisms responsible for opioid-induced constipation.
Original language | English |
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Pages (from-to) | 343-344 |
Number of pages | 2 |
Journal | Journal of Pharmacy and Pharmacology |
Volume | 36 |
Issue number | 5 |
Publication status | Published - 1984 |
ASJC Scopus subject areas
- Pharmaceutical Science
- Pharmacology