The selective κ-compound U-50,488H, at doses producing strong central pharmacological effects (0.5-32 mg kg-1 i.p.) did not delay the intestinal transit of a charcoal meal and had little or no antagonist action against morphine-induced constipation. It appears that κ-opioid receptors are probably not involved in the mechanisms responsible for opioid-induced constipation.
|Number of pages||2|
|Journal||Journal of Pharmacy and Pharmacology|
|Publication status||Published - 1984|
ASJC Scopus subject areas
- Pharmaceutical Science