The organization of dopaminergic and non-dopaminergic mesencephalo-cortical neurons in the rat

Alberto Albanese, Marina Bentivoglio

Research output: Contribution to journalArticle

Abstract

The dopamine containing mesencephalo-cortical pathway was studied in the rat by means of a combined retrograde fluorescent tracing and catecholamine histofluorescence technique. After large injections of the fluorescent retrograde tracer, Evans blue, into the frontal cortex, many neural somata of the ventral midbrain tegmentum were retrogradely labeled; most of the retrogradely labeled neurons also showed catecholamine fluorescence. However, some labeled cells (10-15%) did not show any catecholamine fluorescence. The present findings confirm the existence of a non-dopaminergic (DA) mesencephalo-cortical pathway and describe the topographical interrelationships between its DA and the non-DA cell bodies of origin.

Original languageEnglish
Pages (from-to)421-425
Number of pages5
JournalBrain Research
Volume238
Issue number2
DOIs
Publication statusPublished - Apr 29 1982

Keywords

  • dopamine
  • fluorescent tracers
  • ventral tegmental area

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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