The organization of intrinsic brain activity differs between genders

A resting-state fMRI study in a large cohort of young healthy subjects

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Objectives: To investigate, using resting state (RS) functional MRI (fMRI), gender-related differences of functional connectivity (FC) and functional network connectivity (FNC) of the human brain. Experimental design: One-hundred and four young healthy subjects (48/56 men/women), aged between 20 and 29 years, underwent a 10-min RS fMRI acquisition. Independent component analysis (ICA) and statistical parametric mapping were used to assess gender-related differences in RSNs, with and without correction for regional gray matter (GM) volume. The relationships among all RSNs was also assessed using a FNC method. Principal observations: For all networks, significant between-group differences of RS activity were found. Between-group comparisons of RSNs changed when adjusting for GM volume, as follows: (1) there was only marginal effect on the analysis of sensory (i.e., sensorimotor, visual, and auditory) networks; and (2) there was a significantly increased difference when cognitive networks (apart from one related to attention) were considered. Compared with women, men experienced increased FC in parietal and occipital regions in most RSNs, whereas women experienced a higher RS FC in frontal and temporal regions, and in the cerebellum. When compared to women, increased FNC was found in men between several cognitive and sensory networks, whereas women showed an increased FNC only between attention and right working-memory networks. Conclusions: The organization of intrinsic FC and FNC differ between genders. The detected differences could contribute to the understanding of the known between-gender variation in task-related recruitments, and the patterns of abnormalities detected in neurologic and psychiatric diseases with a gender prevalence.

Original languageEnglish
Pages (from-to)1330-1343
Number of pages14
JournalHuman Brain Mapping
Volume34
Issue number6
DOIs
Publication statusPublished - Jun 2013

Fingerprint

Healthy Volunteers
Magnetic Resonance Imaging
Brain
Occipital Lobe
Parietal Lobe
Temporal Lobe
Nervous System Diseases
Short-Term Memory
Cerebellum
Psychiatry
Research Design
Organizations
Gray Matter

Keywords

  • Functional network connectivity
  • Gender differences
  • Resting state functional MRI

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

@article{0fa8efe0d03a498f84bda1d8810f141c,
title = "The organization of intrinsic brain activity differs between genders: A resting-state fMRI study in a large cohort of young healthy subjects",
abstract = "Objectives: To investigate, using resting state (RS) functional MRI (fMRI), gender-related differences of functional connectivity (FC) and functional network connectivity (FNC) of the human brain. Experimental design: One-hundred and four young healthy subjects (48/56 men/women), aged between 20 and 29 years, underwent a 10-min RS fMRI acquisition. Independent component analysis (ICA) and statistical parametric mapping were used to assess gender-related differences in RSNs, with and without correction for regional gray matter (GM) volume. The relationships among all RSNs was also assessed using a FNC method. Principal observations: For all networks, significant between-group differences of RS activity were found. Between-group comparisons of RSNs changed when adjusting for GM volume, as follows: (1) there was only marginal effect on the analysis of sensory (i.e., sensorimotor, visual, and auditory) networks; and (2) there was a significantly increased difference when cognitive networks (apart from one related to attention) were considered. Compared with women, men experienced increased FC in parietal and occipital regions in most RSNs, whereas women experienced a higher RS FC in frontal and temporal regions, and in the cerebellum. When compared to women, increased FNC was found in men between several cognitive and sensory networks, whereas women showed an increased FNC only between attention and right working-memory networks. Conclusions: The organization of intrinsic FC and FNC differ between genders. The detected differences could contribute to the understanding of the known between-gender variation in task-related recruitments, and the patterns of abnormalities detected in neurologic and psychiatric diseases with a gender prevalence.",
keywords = "Functional network connectivity, Gender differences, Resting state functional MRI",
author = "Massimo Filippi and Paola Valsasina and Paolo Misci and Andrea Falini and Giancarlo Comi and Rocca, {Maria A.}",
year = "2013",
month = "6",
doi = "10.1002/hbm.21514",
language = "English",
volume = "34",
pages = "1330--1343",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - The organization of intrinsic brain activity differs between genders

T2 - A resting-state fMRI study in a large cohort of young healthy subjects

AU - Filippi, Massimo

AU - Valsasina, Paola

AU - Misci, Paolo

AU - Falini, Andrea

AU - Comi, Giancarlo

AU - Rocca, Maria A.

PY - 2013/6

Y1 - 2013/6

N2 - Objectives: To investigate, using resting state (RS) functional MRI (fMRI), gender-related differences of functional connectivity (FC) and functional network connectivity (FNC) of the human brain. Experimental design: One-hundred and four young healthy subjects (48/56 men/women), aged between 20 and 29 years, underwent a 10-min RS fMRI acquisition. Independent component analysis (ICA) and statistical parametric mapping were used to assess gender-related differences in RSNs, with and without correction for regional gray matter (GM) volume. The relationships among all RSNs was also assessed using a FNC method. Principal observations: For all networks, significant between-group differences of RS activity were found. Between-group comparisons of RSNs changed when adjusting for GM volume, as follows: (1) there was only marginal effect on the analysis of sensory (i.e., sensorimotor, visual, and auditory) networks; and (2) there was a significantly increased difference when cognitive networks (apart from one related to attention) were considered. Compared with women, men experienced increased FC in parietal and occipital regions in most RSNs, whereas women experienced a higher RS FC in frontal and temporal regions, and in the cerebellum. When compared to women, increased FNC was found in men between several cognitive and sensory networks, whereas women showed an increased FNC only between attention and right working-memory networks. Conclusions: The organization of intrinsic FC and FNC differ between genders. The detected differences could contribute to the understanding of the known between-gender variation in task-related recruitments, and the patterns of abnormalities detected in neurologic and psychiatric diseases with a gender prevalence.

AB - Objectives: To investigate, using resting state (RS) functional MRI (fMRI), gender-related differences of functional connectivity (FC) and functional network connectivity (FNC) of the human brain. Experimental design: One-hundred and four young healthy subjects (48/56 men/women), aged between 20 and 29 years, underwent a 10-min RS fMRI acquisition. Independent component analysis (ICA) and statistical parametric mapping were used to assess gender-related differences in RSNs, with and without correction for regional gray matter (GM) volume. The relationships among all RSNs was also assessed using a FNC method. Principal observations: For all networks, significant between-group differences of RS activity were found. Between-group comparisons of RSNs changed when adjusting for GM volume, as follows: (1) there was only marginal effect on the analysis of sensory (i.e., sensorimotor, visual, and auditory) networks; and (2) there was a significantly increased difference when cognitive networks (apart from one related to attention) were considered. Compared with women, men experienced increased FC in parietal and occipital regions in most RSNs, whereas women experienced a higher RS FC in frontal and temporal regions, and in the cerebellum. When compared to women, increased FNC was found in men between several cognitive and sensory networks, whereas women showed an increased FNC only between attention and right working-memory networks. Conclusions: The organization of intrinsic FC and FNC differ between genders. The detected differences could contribute to the understanding of the known between-gender variation in task-related recruitments, and the patterns of abnormalities detected in neurologic and psychiatric diseases with a gender prevalence.

KW - Functional network connectivity

KW - Gender differences

KW - Resting state functional MRI

UR - http://www.scopus.com/inward/record.url?scp=84876414201&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876414201&partnerID=8YFLogxK

U2 - 10.1002/hbm.21514

DO - 10.1002/hbm.21514

M3 - Article

VL - 34

SP - 1330

EP - 1343

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

IS - 6

ER -