The origin and function of tumor-associated macrophages

Alberto Mantovani, Barbara Bottazzi, Francesco Colotta, Silvano Sozzani, Luigi Ruco

Research output: Contribution to journalArticlepeer-review


Tumor-associated macrophages (TAM) have a complex relationship with the neoplastic cells of the tumor. On the one hand, the two cell types produce reciprocal growth factors and may be considered to have a symbiotic relationship. On the other hand, TAM can be activated to inhibit tumor growth and destroy neoplastic cells. Here, Alberto Mantovani and colleagues describe this delicate balance and the prospects for its therapeutic manipulation.

Original languageEnglish
Pages (from-to)265-270
Number of pages6
JournalImmunology Today
Issue number7
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Immunology


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