The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood

T. E. Starzl, A. Francavilla, C. G. Halgrimson, F. R. Francavilla, K. A. Porter, T. H. Brown, C. W. Putnam

Research output: Contribution to journalArticlepeer-review

Abstract

The hepatotrophic factors previously reported to be in splanchnic venous blood are pancreatic hormones and specifically insulin and glucagon. Of these, insulin is anabolic and glucagon is mainly catabolic but not exclusively so, since glucagon also has the anabolic effect of stimulating gluconeogenesis. The insulin glucagon relationship and the interrelationship of these hormones to others, such as epinephrine, in the moment to moment regulation of nutrient and hepatic homeostasis is a central fact of liver physiology that should reconcile a number of previously divergent opinions about portoprival syndromes, mechanisms of hepatic atrophy and hyperplasia, and the control of liver regeneration.

Original languageEnglish
Pages (from-to)179-199
Number of pages21
JournalSurgery Gynecology and Obstetrics
Volume137
Issue number2
Publication statusPublished - 1973

ASJC Scopus subject areas

  • Surgery
  • Obstetrics and Gynaecology

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