The other face of ROS: A driver of stem cell expansion in colorectal cancer

Pier Giuseppe Pelicci; Paola Dalton; Marco Giorgio

doi:10.1016/j.stem.2013.05.023

The other face of ROS: A driver of stem cell expansion in colorectal cancer

Pier Giuseppe Pelicci, Paola Dalton, Marco Giorgio

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article

Abstract

APC mutations causing Wnt activation are commonly found in colorectal cancer, but downstream pathways that facilitate tumorigenesis are unclear. In this issue of Cell Stem Cell, Myant et al. (2013) show that Rac1 activation is required for Wnt-driven Lgr5+ intestinal stem cell transformation through ROS production and NF-kB activation.

Original language	English
Pages (from-to)	635-636
Number of pages	2
Journal	Cell Stem Cell
Volume	12
Issue number	6
DOIs	https://doi.org/10.1016/j.stem.2013.05.023
Publication status	Published - Jun 6 2013

ASJC Scopus subject areas

Molecular Medicine
Genetics
Cell Biology
Medicine(all)

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Pelicci, P. G., Dalton, P., & Giorgio, M. (2013). The other face of ROS: A driver of stem cell expansion in colorectal cancer. Cell Stem Cell, 12(6), 635-636. https://doi.org/10.1016/j.stem.2013.05.023

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