The other face of ROS: A driver of stem cell expansion in colorectal cancer

Research output: Contribution to journalArticle

Abstract

APC mutations causing Wnt activation are commonly found in colorectal cancer, but downstream pathways that facilitate tumorigenesis are unclear. In this issue of Cell Stem Cell, Myant et al. (2013) show that Rac1 activation is required for Wnt-driven Lgr5+ intestinal stem cell transformation through ROS production and NF-kB activation.

Original languageEnglish
Pages (from-to)635-636
Number of pages2
JournalCell Stem Cell
Volume12
Issue number6
DOIs
Publication statusPublished - Jun 6 2013

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology
  • Medicine(all)

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