TY - JOUR
T1 - The other face of ROS
T2 - A driver of stem cell expansion in colorectal cancer
AU - Pelicci, Pier Giuseppe
AU - Dalton, Paola
AU - Giorgio, Marco
PY - 2013/6/6
Y1 - 2013/6/6
N2 - APC mutations causing Wnt activation are commonly found in colorectal cancer, but downstream pathways that facilitate tumorigenesis are unclear. In this issue of Cell Stem Cell, Myant et al. (2013) show that Rac1 activation is required for Wnt-driven Lgr5+ intestinal stem cell transformation through ROS production and NF-kB activation.
AB - APC mutations causing Wnt activation are commonly found in colorectal cancer, but downstream pathways that facilitate tumorigenesis are unclear. In this issue of Cell Stem Cell, Myant et al. (2013) show that Rac1 activation is required for Wnt-driven Lgr5+ intestinal stem cell transformation through ROS production and NF-kB activation.
UR - http://www.scopus.com/inward/record.url?scp=84878870632&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878870632&partnerID=8YFLogxK
U2 - 10.1016/j.stem.2013.05.023
DO - 10.1016/j.stem.2013.05.023
M3 - Article
C2 - 23746969
AN - SCOPUS:84878870632
VL - 12
SP - 635
EP - 636
JO - Cell Stem Cell
JF - Cell Stem Cell
SN - 1934-5909
IS - 6
ER -