The Outcome of Cholangitis after Percutaneous Biliary Drainage in Neoplastic Jaundice

Riccardo A. Audisio, Carlo Morosi, Guido Cozzi, Alessandra Pestalozza, Aldo Severini, Federico Bozzetti, Leandro Gennari, Massimo Bellomi, Paola Pisani

Research output: Contribution to journalArticle

Abstract

The purpose of this paper is to evaluate factors affecting the outcome of cholangitis after PTBD in jaundiced cancer patients. Twenty nine patients with neoplastic jaundice (male/female ratio 13/16, median age 55 years) with full clinical data, were treated by PTBD and developed cholangitis at a median of 9 days later. Four patients (14%) died of biliary sepsis a median of one month after PTBD while the other 25 survived a median of 6 months, with one week median duration of cholangitis. The probability of the cholangitis resolving was analyzed by time to resolution and it was found that 50% and 100% of the recoveries occurred 5 and 9 months respectively from the onset of the complication. The series was analyzed to determine the role of several variables (disease/patient/treatment related) in the resolution of cholangitis. Only a low stricture site, a large initial drainage catheter (10F) and a temperature increase exceeding 39° C were correlated with a positive outcome. We conclude that PTBD-related cholangitis has, in our experience, a good chance of cure, low mortality rate and satisfactory 6 months median survival.

Original languageEnglish
Pages (from-to)287-293
Number of pages7
JournalHPB Surgery
Volume6
Issue number4
DOIs
Publication statusPublished - 1993

Keywords

  • Biliary drainage
  • cholangitis
  • jaundice
  • PTBD

ASJC Scopus subject areas

  • Hepatology
  • Surgery

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    Audisio, R. A., Morosi, C., Cozzi, G., Pestalozza, A., Severini, A., Bozzetti, F., Gennari, L., Bellomi, M., & Pisani, P. (1993). The Outcome of Cholangitis after Percutaneous Biliary Drainage in Neoplastic Jaundice. HPB Surgery, 6(4), 287-293. https://doi.org/10.1155/1993/17078