The ovarian renin-angiotensin system

J. E. Sealey, F. W. Quimby, J. Itskovitz, S. Rubattu

Research output: Contribution to journalReview articlepeer-review


All of the components of the renin-angiotensin system are present in the ovary. The possible role of this system in reproductive function is beginning to be uncovered. In contrast to the circulating renal renin system, which is regulated by sodium, pressure, and β-adrenergic sympathetic drive, the ovarian renin-angiotensin system appears to be regulated by gonadotropins. The characteristics of the ovarian renin-angiotensin system are different from those of the classic circulating hormonal system. In the ovarian system, prorenin appears to be the principal secretory product rather than renin. This has led to speculation that prorenin has intrinsic catalytic renin-like activity in vivo, and itself cleaves angiotensin I from angiotensinogen. This property of prorenin would allow separation of the functions of circulating and tissue renin-angiotensin systems. The testis, placenta, and uterus also express the renin gene, predominantly as prorenin. Thus, tissue prorenin-angiotensin systems may be present in all reproductive organs, suggesting vital roles for angiotensin in reproductive function and embryonic development.

Original languageEnglish
Pages (from-to)213-237
Number of pages25
JournalFrontiers in Neuroendocrinology
Issue number3
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrine and Autonomic Systems

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