The ovariectomized ewe model in the evaluation of biomaterials for prosthetic devices in spinal fixation

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Abstract

The effect of surgical ovariectomy on cancellous bone was investigated by comparing mechanical properties and microarchitectural characteristics of the lumbar vertebrae in ovariectomized and sham-operated ewes. Eighteen mongrel ewes, 4±1 years old, were randomly divided into three groups: 6 animals served as a control group (Baseline), 6 were bilaterally ovariectomized (OVX), and the others were used as a sham-operated group (SHAM). OVX and SHAM ewes were euthanized 24 months after surgery; the L5 vertebrae were processed for mechanical and histomorphometric analyses. Maximum load, maximum strength (p

Original languageEnglish
Pages (from-to)814-820
Number of pages7
JournalInternational Journal of Artificial Organs
Volume24
Issue number11
Publication statusPublished - 2001

Keywords

  • Biomaterials
  • Osteopenia
  • Osteoporosis
  • Sheep
  • Spine

ASJC Scopus subject areas

  • Biophysics

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