Abstract
Background: The overlap syndrome between primary biliary cirrhosis and primary sclerosing cholangitis is an extremely rare condition that has been reported in only six published cases so far. Methods: Here we report two cases showing the clinical manifestations of both primary biliary cirrhosis and primary sclerosing cholangitis. Results: In one case the overlap condition was associated with psoriatric arthritis, and the patient successfully underwent dual treatment with ursodeoxycholic acid and the anti-tumour necrosis factor-alpha agent adalimumab. In the second case, the predominant condition was, initially, an antimitochondrial antibody-negative primary biliary cirrhosis with progressive course towards end-stage liver disease; the patient then developed either antimitochondrial antibody positivity or changes in the biliary tree compatible with primary sclerosing cholangitis. Conclusions: These two cases add information on a controversial issue in the literature, and indicate the importance of recognizing a possible overlap syndrome to optimize treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 432-435 |
| Number of pages | 4 |
| Journal | Digestive and Liver Disease |
| Volume | 47 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 1 2015 |
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Keywords
- Overlap syndrome
- Primary biliary cirrhosis
- Primary sclerosing cholangitis
ASJC Scopus subject areas
- Gastroenterology
- Hepatology
- Medicine(all)
Cite this
The overlap syndrome between primary biliary cirrhosis and primary sclerosing cholangitis. / Floreani, Annarosa; Motta, Raffaella; Cazzagon, Nora; Franceschet, Irene; Roncalli, Massimo; Del Ross, Teresa; Rosina, Floriano; Lleo, Ana; Mescoli, Claudia; Colloredo, Guido; Invernizzi, Pietro.
In: Digestive and Liver Disease, Vol. 47, No. 5, 01.05.2015, p. 432-435.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The overlap syndrome between primary biliary cirrhosis and primary sclerosing cholangitis
AU - Floreani, Annarosa
AU - Motta, Raffaella
AU - Cazzagon, Nora
AU - Franceschet, Irene
AU - Roncalli, Massimo
AU - Del Ross, Teresa
AU - Rosina, Floriano
AU - Lleo, Ana
AU - Mescoli, Claudia
AU - Colloredo, Guido
AU - Invernizzi, Pietro
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Background: The overlap syndrome between primary biliary cirrhosis and primary sclerosing cholangitis is an extremely rare condition that has been reported in only six published cases so far. Methods: Here we report two cases showing the clinical manifestations of both primary biliary cirrhosis and primary sclerosing cholangitis. Results: In one case the overlap condition was associated with psoriatric arthritis, and the patient successfully underwent dual treatment with ursodeoxycholic acid and the anti-tumour necrosis factor-alpha agent adalimumab. In the second case, the predominant condition was, initially, an antimitochondrial antibody-negative primary biliary cirrhosis with progressive course towards end-stage liver disease; the patient then developed either antimitochondrial antibody positivity or changes in the biliary tree compatible with primary sclerosing cholangitis. Conclusions: These two cases add information on a controversial issue in the literature, and indicate the importance of recognizing a possible overlap syndrome to optimize treatment.
AB - Background: The overlap syndrome between primary biliary cirrhosis and primary sclerosing cholangitis is an extremely rare condition that has been reported in only six published cases so far. Methods: Here we report two cases showing the clinical manifestations of both primary biliary cirrhosis and primary sclerosing cholangitis. Results: In one case the overlap condition was associated with psoriatric arthritis, and the patient successfully underwent dual treatment with ursodeoxycholic acid and the anti-tumour necrosis factor-alpha agent adalimumab. In the second case, the predominant condition was, initially, an antimitochondrial antibody-negative primary biliary cirrhosis with progressive course towards end-stage liver disease; the patient then developed either antimitochondrial antibody positivity or changes in the biliary tree compatible with primary sclerosing cholangitis. Conclusions: These two cases add information on a controversial issue in the literature, and indicate the importance of recognizing a possible overlap syndrome to optimize treatment.
KW - Overlap syndrome
KW - Primary biliary cirrhosis
KW - Primary sclerosing cholangitis
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UR - http://www.scopus.com/inward/citedby.url?scp=84928823977&partnerID=8YFLogxK
U2 - 10.1016/j.dld.2015.02.002
DO - 10.1016/j.dld.2015.02.002
M3 - Article
C2 - 25747115
AN - SCOPUS:84928823977
VL - 47
SP - 432
EP - 435
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
IS - 5
ER -