The oxygen-release capacity of red blood cells in insulin-dependent diabetics after artificial pancreas

Roberto Torella, Riccardo Giunta, Giuseppe Scognamiglio, Dario Giugliano, Paolo Di Pinto, Antonio Ceriello, Franco Grandillo

Research output: Contribution to journalArticle

Abstract

Oxygen-release capacity of the red blood cells was investigated in non-acidotic insulin-dependent diabetics before and after the achievement of strict metabolic control with the aid of the artificial pancreas. P50std (oxygen tension at 50% oxygen saturation) values were low in basal condition and returned to normal after the 24-h treatment period. No significant changes were observed in the content of red cell 2,3-diphosphoglycerate nor in the acid-base balance. Only the labile form of glycosylated hemoglobin showed significant decreases after treatment. These results suggest that insulin-dependent diabetics may have a state of relative tissue hypoxia which can be easily overcome by the achievement of strict metabolic control.

Original languageEnglish
Pages (from-to)281-286
Number of pages6
JournalActa Diabetologica Latina
Volume21
Issue number3
DOIs
Publication statusPublished - Sep 1984

Fingerprint

Artificial Pancreas
Erythrocytes
Insulin
Oxygen
2,3-Diphosphoglycerate
Acid-Base Equilibrium
Glycosylated Hemoglobin A

Keywords

  • 2,3-Diphosphoglycerate
  • Artificial pancreas
  • Glycosylated hemoglobin
  • Insulin-dependent diabetes
  • Oxygen affinity of hemoglobin

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

The oxygen-release capacity of red blood cells in insulin-dependent diabetics after artificial pancreas. / Torella, Roberto; Giunta, Riccardo; Scognamiglio, Giuseppe; Giugliano, Dario; Di Pinto, Paolo; Ceriello, Antonio; Grandillo, Franco.

In: Acta Diabetologica Latina, Vol. 21, No. 3, 09.1984, p. 281-286.

Research output: Contribution to journalArticle

Torella, R, Giunta, R, Scognamiglio, G, Giugliano, D, Di Pinto, P, Ceriello, A & Grandillo, F 1984, 'The oxygen-release capacity of red blood cells in insulin-dependent diabetics after artificial pancreas', Acta Diabetologica Latina, vol. 21, no. 3, pp. 281-286. https://doi.org/10.1007/BF02642902
Torella, Roberto ; Giunta, Riccardo ; Scognamiglio, Giuseppe ; Giugliano, Dario ; Di Pinto, Paolo ; Ceriello, Antonio ; Grandillo, Franco. / The oxygen-release capacity of red blood cells in insulin-dependent diabetics after artificial pancreas. In: Acta Diabetologica Latina. 1984 ; Vol. 21, No. 3. pp. 281-286.
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