The p53 family and stem cell biology

Massimiliano Agostini, Alessandro Rufini, Edward T W Bampton, Francesca Bernassola, Gerry Melino, Richard A. Knight

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Stem cells are characterized by the ability to renew themselves (self-renewal) and the capability to generate all the cells within the human body. These features are achieved by a fine-tuned control of proliferation and maintenance of the undifferentiated condition. Transcription factors such as Nanog, Sox, and Oct-4 and extrinsic factors (LIF, BMP, and FGF) have been demonstrated to play a critical role in the regulation of stemness. Because stem cells are under consideration in clinics for cell-based therapy, it is important to understand the molecular mechanisms underlying stemness. In this chapter, we revisit stem cell biology and add a new layer of complexity. In particular, we will discuss the role of the p53 family (p53, p63, and p73) in the regulation of self-renewal, proliferation, and differentiation of stem cells.

Original languageEnglish
Title of host publicationp53 in the Clinics
PublisherSpringer New York
Pages65-76
Number of pages12
Volume9781461436768
ISBN (Print)9781461436768, 1461436753, 9781461436751
DOIs
Publication statusPublished - May 1 2013

ASJC Scopus subject areas

  • Medicine(all)

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    Agostini, M., Rufini, A., Bampton, E. T. W., Bernassola, F., Melino, G., & Knight, R. A. (2013). The p53 family and stem cell biology. In p53 in the Clinics (Vol. 9781461436768, pp. 65-76). Springer New York. https://doi.org/10.1007/978-1-4614-3676-8_4