Abstract
We have isolated a paired-type homeobox gene Dmbx1, previously known as Atx (Development 128 (2001) 4789), from chick and mouse. Sequence similarity reveals that this gene is highly related to the Otx genes. Expression of Dmbx1 commences during gastrulation, when transcripts are detected in a crescent around the anterior neural plate. As development progresses, Dmbx1 marks the prospective midbrain and pretectum. Dmbx1 shares its caudal border of expression with Otx2, while expression is sharply delimited rostrally by the synencephalic-parencephalic boundary, later becoming restricted to the posterior synencephalon. At later stages, Dmbx1 is expressed in dynamic domains of the hindbrain and spinal cord. Additional sites of expression comprise stomodeal ectoderm and foregut endoderm, presomitic mesoderm, and the nasal pit.
| Original language | English |
|---|---|
| Pages (from-to) | 213-217 |
| Number of pages | 5 |
| Journal | Mechanisms of Development |
| Volume | 114 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- Atx
- Chick
- Dmbx1
- Isthmus
- Mouse
- Nasal pit
- Rhombencephalon
- Stomodeal ectoderm
ASJC Scopus subject areas
- Developmental Biology
- Developmental Neuroscience
Cite this
The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum. / Gogoi, Robindra N.; Schubert, Frank R.; Martinez-Barbera, Juan Pedro; Acampora, Dario; Simeone, Antonio; Lumsden, Andrew.
In: Mechanisms of Development, Vol. 114, No. 1-2, 2002, p. 213-217.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum
AU - Gogoi, Robindra N.
AU - Schubert, Frank R.
AU - Martinez-Barbera, Juan Pedro
AU - Acampora, Dario
AU - Simeone, Antonio
AU - Lumsden, Andrew
PY - 2002
Y1 - 2002
N2 - We have isolated a paired-type homeobox gene Dmbx1, previously known as Atx (Development 128 (2001) 4789), from chick and mouse. Sequence similarity reveals that this gene is highly related to the Otx genes. Expression of Dmbx1 commences during gastrulation, when transcripts are detected in a crescent around the anterior neural plate. As development progresses, Dmbx1 marks the prospective midbrain and pretectum. Dmbx1 shares its caudal border of expression with Otx2, while expression is sharply delimited rostrally by the synencephalic-parencephalic boundary, later becoming restricted to the posterior synencephalon. At later stages, Dmbx1 is expressed in dynamic domains of the hindbrain and spinal cord. Additional sites of expression comprise stomodeal ectoderm and foregut endoderm, presomitic mesoderm, and the nasal pit.
AB - We have isolated a paired-type homeobox gene Dmbx1, previously known as Atx (Development 128 (2001) 4789), from chick and mouse. Sequence similarity reveals that this gene is highly related to the Otx genes. Expression of Dmbx1 commences during gastrulation, when transcripts are detected in a crescent around the anterior neural plate. As development progresses, Dmbx1 marks the prospective midbrain and pretectum. Dmbx1 shares its caudal border of expression with Otx2, while expression is sharply delimited rostrally by the synencephalic-parencephalic boundary, later becoming restricted to the posterior synencephalon. At later stages, Dmbx1 is expressed in dynamic domains of the hindbrain and spinal cord. Additional sites of expression comprise stomodeal ectoderm and foregut endoderm, presomitic mesoderm, and the nasal pit.
KW - Atx
KW - Chick
KW - Dmbx1
KW - Isthmus
KW - Mouse
KW - Nasal pit
KW - Rhombencephalon
KW - Stomodeal ectoderm
UR - http://www.scopus.com/inward/record.url?scp=0036011269&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036011269&partnerID=8YFLogxK
U2 - 10.1016/S0925-4773(02)00067-9
DO - 10.1016/S0925-4773(02)00067-9
M3 - Article
C2 - 12175514
AN - SCOPUS:0036011269
VL - 114
SP - 213
EP - 217
JO - Mechanisms of Development
JF - Mechanisms of Development
SN - 0925-4773
IS - 1-2
ER -