The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum

Robindra N. Gogoi, Frank R. Schubert, Juan Pedro Martinez-Barbera, Dario Acampora, Antonio Simeone, Andrew Lumsden

Research output: Contribution to journalArticle

Abstract

We have isolated a paired-type homeobox gene Dmbx1, previously known as Atx (Development 128 (2001) 4789), from chick and mouse. Sequence similarity reveals that this gene is highly related to the Otx genes. Expression of Dmbx1 commences during gastrulation, when transcripts are detected in a crescent around the anterior neural plate. As development progresses, Dmbx1 marks the prospective midbrain and pretectum. Dmbx1 shares its caudal border of expression with Otx2, while expression is sharply delimited rostrally by the synencephalic-parencephalic boundary, later becoming restricted to the posterior synencephalon. At later stages, Dmbx1 is expressed in dynamic domains of the hindbrain and spinal cord. Additional sites of expression comprise stomodeal ectoderm and foregut endoderm, presomitic mesoderm, and the nasal pit.

Original languageEnglish
Pages (from-to)213-217
Number of pages5
JournalMechanisms of Development
Volume114
Issue number1-2
DOIs
Publication statusPublished - 2002

Fingerprint

Homeobox Genes
Mesencephalon
Neural Plate
Gastrulation
Rhombencephalon
Endoderm
Ectoderm
Mesoderm
Nose
Genes
Spinal Cord
Pretectal Region

Keywords

  • Atx
  • Chick
  • Dmbx1
  • Isthmus
  • Mouse
  • Nasal pit
  • Rhombencephalon
  • Stomodeal ectoderm

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Gogoi, R. N., Schubert, F. R., Martinez-Barbera, J. P., Acampora, D., Simeone, A., & Lumsden, A. (2002). The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum. Mechanisms of Development, 114(1-2), 213-217. https://doi.org/10.1016/S0925-4773(02)00067-9

The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum. / Gogoi, Robindra N.; Schubert, Frank R.; Martinez-Barbera, Juan Pedro; Acampora, Dario; Simeone, Antonio; Lumsden, Andrew.

In: Mechanisms of Development, Vol. 114, No. 1-2, 2002, p. 213-217.

Research output: Contribution to journalArticle

Gogoi, RN, Schubert, FR, Martinez-Barbera, JP, Acampora, D, Simeone, A & Lumsden, A 2002, 'The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum', Mechanisms of Development, vol. 114, no. 1-2, pp. 213-217. https://doi.org/10.1016/S0925-4773(02)00067-9
Gogoi RN, Schubert FR, Martinez-Barbera JP, Acampora D, Simeone A, Lumsden A. The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum. Mechanisms of Development. 2002;114(1-2):213-217. https://doi.org/10.1016/S0925-4773(02)00067-9
Gogoi, Robindra N. ; Schubert, Frank R. ; Martinez-Barbera, Juan Pedro ; Acampora, Dario ; Simeone, Antonio ; Lumsden, Andrew. / The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum. In: Mechanisms of Development. 2002 ; Vol. 114, No. 1-2. pp. 213-217.
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