The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum

Robindra N. Gogoi; Frank R. Schubert; Juan Pedro Martinez-Barbera; Dario Acampora; Antonio Simeone; Andrew Lumsden

doi:10.1016/S0925-4773(02)00067-9

The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum

Robindra N. Gogoi, Frank R. Schubert, Juan Pedro Martinez-Barbera, Dario Acampora, Antonio Simeone, Andrew Lumsden

www.neuromed.it

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Abstract

We have isolated a paired-type homeobox gene Dmbx1, previously known as Atx (Development 128 (2001) 4789), from chick and mouse. Sequence similarity reveals that this gene is highly related to the Otx genes. Expression of Dmbx1 commences during gastrulation, when transcripts are detected in a crescent around the anterior neural plate. As development progresses, Dmbx1 marks the prospective midbrain and pretectum. Dmbx1 shares its caudal border of expression with Otx2, while expression is sharply delimited rostrally by the synencephalic-parencephalic boundary, later becoming restricted to the posterior synencephalon. At later stages, Dmbx1 is expressed in dynamic domains of the hindbrain and spinal cord. Additional sites of expression comprise stomodeal ectoderm and foregut endoderm, presomitic mesoderm, and the nasal pit.

Original language	English
Pages (from-to)	213-217
Number of pages	5
Journal	Mechanisms of Development
Volume	114
Issue number	1-2
DOIs	https://doi.org/10.1016/S0925-4773(02)00067-9
Publication status	Published - 2002

Keywords

Atx
Chick
Dmbx1
Isthmus
Mouse
Nasal pit
Rhombencephalon
Stomodeal ectoderm

ASJC Scopus subject areas

Developmental Biology
Developmental Neuroscience

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title = "The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum",

abstract = "We have isolated a paired-type homeobox gene Dmbx1, previously known as Atx (Development 128 (2001) 4789), from chick and mouse. Sequence similarity reveals that this gene is highly related to the Otx genes. Expression of Dmbx1 commences during gastrulation, when transcripts are detected in a crescent around the anterior neural plate. As development progresses, Dmbx1 marks the prospective midbrain and pretectum. Dmbx1 shares its caudal border of expression with Otx2, while expression is sharply delimited rostrally by the synencephalic-parencephalic boundary, later becoming restricted to the posterior synencephalon. At later stages, Dmbx1 is expressed in dynamic domains of the hindbrain and spinal cord. Additional sites of expression comprise stomodeal ectoderm and foregut endoderm, presomitic mesoderm, and the nasal pit.",

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AU - Simeone, Antonio

AU - Lumsden, Andrew

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