The Pamela study: Main findings and perspectives

Michele Bombelli, Elena Toso, Maria Peronio, Danilo Fodri, Marco Volpe, Gianmaria Brambilla, Rita Facchetti, Roberto Sega, Guido Grassi, Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review

Abstract

PAMELA (Pressioni Arteriose Monitorate E Loro Associazioni) is an epidemiological study, originally designed to determine the normality of home and ambulatory blood pressure values. The study was performed on 3,200 subjects, aged 25 to 74 years, randomly selected from the general population of Monza (Milan, Italy). In the study context we performed clinical, home and ambulatory blood pressure measurements, echocardiographic assessment of cardiac structure and function as well as laboratory examinations (glucose and lipids). Personal and family histories were collected. The same procedures were repeated 10 years later. During a 12-year follow-up, the incident cardiovascular events were validated. Cardiovascular and all-cause fatal events were collected for a 16-year follow-up. This article will review the main results of the PAMELA study, with particular emphasis on (1) the prognostic value of the different blood pressure measurements, (2) the relationships between metabolic variables and blood pressure and (3) the clinical relevance and prognostic importance of left ventricular mass values and alterations.

Original languageEnglish
Pages (from-to)238-243
Number of pages6
JournalCurrent Hypertension Reports
Volume15
Issue number3
DOIs
Publication statusPublished - Jun 2013

Keywords

  • Ambulatory blood pressure
  • Blood glucose
  • Body mass index
  • Clinical blood pressure
  • Home blood pressure
  • Left ventricular mass index
  • Masked hypertension
  • Metabolic syndrome
  • Waist circumference
  • White-coat hypertension

ASJC Scopus subject areas

  • Internal Medicine

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