The Pan European Emesis Registry (PEER): A critical appraisal of the Italian experience

Davide Pastorelli, Maria Adelia Locatelli, Barbara Melotti, Carmela Pisano, Salvatore Turano, Umberto Mellino, Nicoletta Provinciali, Paolo Marchetti, Claudio Dazzi, Massimiliano Berretta, Anna Giordano, Vito Lorusso

Research output: Contribution to journalArticlepeer-review


Purpose: Data froma large European prospective observational study were analysed to describe the antiemetic prescribing pattern for chemotherapy-induced nausea and vomiting (CINV) in Italian clinical practice. Methods: Post hoc analysis of the Pan European Emesis Registry in chemo-naïve adults initiating single-day highly or moderately emetogenic chemotherapy (HEC or MEC) for cancer. Results: A total of 211 eligible patients were enrolled in the Italian centres, 180 were included in the analyses for cycle 1; 50.6% received MEC. The use of guideline-consistent CINV prophylaxis (GCCP) varied substantially between acute and delayed phases (54.4% during the acute phase vs. 29.4% in the overall 120-hour study period, acute plus delayed phases). Neurokinin-1 receptor antagonist was added to the prophylaxis with dexamethasonez5-hydroxytryptamine type 3 receptor antagonists in only 11.1% of patients (vs. 57.2% of the entire European study population). In the GCCP group, the complete response rate was significantly higher than that recorded in the guideline-inconsistent CINV prophylaxis (GICP) group (75.5 vs. 53.5%, P 5 0.006). Conclusion: The proportion of guideline-consistent antiemetic therapy was quite low in the Italian population as it was in the overall European population. The implementation of specific guidelines' recommendations for chemotherapeutic regimens administered according to standard protocols could be considered as a means to reduce the burden of CINV.

Original languageEnglish
Pages (from-to)309-317
Number of pages9
JournalJournal of Chemotherapy
Issue number5
Publication statusPublished - Oct 2013


  • Antiemetic therapy
  • CINV
  • Emesis
  • Guidelines
  • Nausea

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Oncology
  • Pharmacology


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