The parental origin of hydatidiform moles and blighted ova: Molecular probing with hypervariable DNA polymorphisms

E. Trabetti, R. Galavotti, L. Zanini, E. Zardini, N. Zatti, F. Bernardi, A. Notarangelo, A. I. Croce, P. F. Pignatti, P. Gasparini

Research output: Contribution to journalArticle

Abstract

The androgenetic origin of hydatidiform moles, due to a monospermic or dispermic mechanism, has been reported, and a possible pathogenetic relation with blighted ova suggested. To evaluate the origin of hydatidiform moles and their genetic relationship with blighted ova we investigated a series of samples, utilizing several hypervariable DNA polymorphisms by Southern blotting or PCR. Seven complete or partial hydatidiform mole and 49 blighted ovum cases were investigated. The results confirm the androgenetic origin of complete hydatidiform moles, which were always due in our sample to a monospermic mechanism. Our data exclude a relationship between hydatidiform moles and blighted ova, as in the latter a mixed paternal and maternal DNA contribution was always shown. A high incidence of chromosomal abnormalities in blighted ova was also found.

Original languageEnglish
Pages (from-to)325-329
Number of pages5
JournalMolecular and Cellular Probes
Volume7
Issue number4
DOIs
Publication statusPublished - 1993

Keywords

  • blighted ovum
  • DNA
  • hydatidiform mole
  • hypervariable polymorphisms

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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    Trabetti, E., Galavotti, R., Zanini, L., Zardini, E., Zatti, N., Bernardi, F., Notarangelo, A., Croce, A. I., Pignatti, P. F., & Gasparini, P. (1993). The parental origin of hydatidiform moles and blighted ova: Molecular probing with hypervariable DNA polymorphisms. Molecular and Cellular Probes, 7(4), 325-329. https://doi.org/10.1006/mcpr.1993.1046