El significado patogenico de la inflamacion en la esclerosis multiple

Translated title of the contribution: The pathogenic role of inflammation in multiple sclerosis

G. Martino, R. Furlan, P. L. Poliani

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction. Multiple sclerosis (MS) is characterized by the presence in the central nervous system (CNS) of perivascular inflammatory infiltrates containing auto-reactive T and B cells and activated macrophages thus indicating that MS is a T cell-mediated CNS-confined chronic inflammatory demyelinating disease in which the ultimate effector cell is the activated macrophage. Development. The inflammatory process, leading to patchy demyelination and axonal loss, is mainly sustained by pro-inflammatory cytokines that modulate at different levels the pathogenic process underlying MS. Cytokines can; 1. Sustain the 'putative' CNS-confined inflammatory process leading to the development of myelin-specific T cells; 2. Activate circulating myelin-specific T cells and shape their repertoire (Th1 versus Th2 pattern); 3. Induce the CNS recruitment of non antigen specific T cells and myelinotoxic effector cells (monocyte/macrophages) from the periphery, and 4. Cause direct oligodendrotoxicity (TNFα) or induce the secretion of myelinotoxic substances. The present chapter will focus on the mechanisms sustaining the activity of pro-inflammatory cytokines in MS pathogenesis.

Translated title of the contributionThe pathogenic role of inflammation in multiple sclerosis
Original languageSpanish
Pages (from-to)1213-1217
Number of pages5
JournalRevista de Neurologia
Volume30
Issue number12
Publication statusPublished - Jun 16 2000

Keywords

  • Cytokines
  • Glial cells
  • Inflammation
  • Inflammatory mediators
  • Multiple sclerosis
  • T cells

ASJC Scopus subject areas

  • Clinical Neurology

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