The pathologic and molecular landscape of esophageal squamous cell carcinogenesis

Gianluca Businello; Paola Parente; Luca Mastracci; Gianmaria Pennelli; Giulia Traverso; Massimo Milione; Elena Bellan; Mauro Michelotto; Andromachi Kotsafti; Federica Grillo; Matteo Fassan

doi:10.3390/cancers12082160

The pathologic and molecular landscape of esophageal squamous cell carcinogenesis

Gianluca Businello, Paola Parente, Luca Mastracci, Gianmaria Pennelli, Giulia Traverso, Massimo Milione, Elena Bellan, Mauro Michelotto, Andromachi Kotsafti, Federica Grillo, Matteo Fassan

Research output: Contribution to journal › Review article › peer-review

Abstract

Esophageal squamous cell carcinoma represents the most common histotype of epithelial neoplasm occurring within esophageal mucosa worldwide. Despite the comprehensive molecular characterization of this entity, to date no significant targeted therapy has been introduced into clinical practice. In this review, we describe the molecular landscape of esophageal squamous cell carcinoma based on the most recent literature. Moreover, we focus on other rare variants and on the relationship with head and neck squamous cell carcinomas.

Original language	English
Article number	2160
Pages (from-to)	1-19
Number of pages	19
Journal	Cancers
Volume	12
Issue number	8
DOIs	https://doi.org/10.3390/cancers12082160
Publication status	Published - Aug 2020

Keywords

Biomarkers
Carcinogenesis
Esophageal cancer
Molecular landscape
Squamous cell carcinoma

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.3390/cancers12082160

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The pathologic and molecular landscape of esophageal squamous cell carcinogenesis. / Businello, Gianluca; Parente, Paola; Mastracci, Luca; Pennelli, Gianmaria; Traverso, Giulia; Milione, Massimo; Bellan, Elena; Michelotto, Mauro; Kotsafti, Andromachi ; Grillo, Federica; Fassan, Matteo.

In: Cancers, Vol. 12, No. 8, 2160, 08.2020, p. 1-19.

Research output: Contribution to journal › Review article › peer-review

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