The pathologic and molecular landscape of esophageal squamous cell carcinogenesis

Gianluca Businello, Paola Parente, Luca Mastracci, Gianmaria Pennelli, Giulia Traverso, Massimo Milione, Elena Bellan, Mauro Michelotto, Andromachi Kotsafti, Federica Grillo, Matteo Fassan

Research output: Contribution to journalReview articlepeer-review

Abstract

Esophageal squamous cell carcinoma represents the most common histotype of epithelial neoplasm occurring within esophageal mucosa worldwide. Despite the comprehensive molecular characterization of this entity, to date no significant targeted therapy has been introduced into clinical practice. In this review, we describe the molecular landscape of esophageal squamous cell carcinoma based on the most recent literature. Moreover, we focus on other rare variants and on the relationship with head and neck squamous cell carcinomas.

Original languageEnglish
Article number2160
Pages (from-to)1-19
Number of pages19
JournalCancers
Volume12
Issue number8
DOIs
Publication statusPublished - Aug 2020

Keywords

  • Biomarkers
  • Carcinogenesis
  • Esophageal cancer
  • Molecular landscape
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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