TY - JOUR
T1 - The pathologic and molecular landscape of esophageal squamous cell carcinogenesis
AU - Businello, Gianluca
AU - Parente, Paola
AU - Mastracci, Luca
AU - Pennelli, Gianmaria
AU - Traverso, Giulia
AU - Milione, Massimo
AU - Bellan, Elena
AU - Michelotto, Mauro
AU - Kotsafti, Andromachi
AU - Grillo, Federica
AU - Fassan, Matteo
PY - 2020/8
Y1 - 2020/8
N2 - Esophageal squamous cell carcinoma represents the most common histotype of epithelial neoplasm occurring within esophageal mucosa worldwide. Despite the comprehensive molecular characterization of this entity, to date no significant targeted therapy has been introduced into clinical practice. In this review, we describe the molecular landscape of esophageal squamous cell carcinoma based on the most recent literature. Moreover, we focus on other rare variants and on the relationship with head and neck squamous cell carcinomas.
AB - Esophageal squamous cell carcinoma represents the most common histotype of epithelial neoplasm occurring within esophageal mucosa worldwide. Despite the comprehensive molecular characterization of this entity, to date no significant targeted therapy has been introduced into clinical practice. In this review, we describe the molecular landscape of esophageal squamous cell carcinoma based on the most recent literature. Moreover, we focus on other rare variants and on the relationship with head and neck squamous cell carcinomas.
KW - Biomarkers
KW - Carcinogenesis
KW - Esophageal cancer
KW - Molecular landscape
KW - Squamous cell carcinoma
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U2 - 10.3390/cancers12082160
DO - 10.3390/cancers12082160
M3 - Review article
AN - SCOPUS:85090539588
VL - 12
SP - 1
EP - 19
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 8
M1 - 2160
ER -