The Pathologic Basis of Recovery

Nupoor Narula, Manuela Agozzino, Fabrizio Gazzoli, Monica Concardi, Francesco Pagani, Valentina Favalli, Takahide Kodama, Alessandro Mazzola, Andrea M. D'Armini, Eloisa Arbustini

Research output: Contribution to journalArticlepeer-review

Abstract

More patients with end-stage heart failure are now being supported by left ventricular assist devices (LVAD) as a bridge to heart transplant. The LVAD unloads the failing heart and modifies the myocardial structure, with regression of left ventricular hypertrophy. The regression of hypertrophy has been reported histomorphologically in paired samples of myocardial tissues obtained from the same patient at the time of LVAD implantation and the heart excised at transplant. The understanding of the mechanisms of recovery may contribute to strategic development for LVAD weaning and the use of LVAD as a destination therapy.

Original languageEnglish
JournalHeart Failure Clinics
Volume10
Issue number1 SUPPL.
DOIs
Publication statusPublished - Jan 2014

Keywords

  • Left ventricular assist device
  • Reverse remodeling
  • Unloading left ventricle

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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