The Pathologic Basis of Recovery

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

More patients with end-stage heart failure are now being supported by left ventricular assist devices (LVAD) as a bridge to heart transplant. The LVAD unloads the failing heart and modifies the myocardial structure, with regression of left ventricular hypertrophy. The regression of hypertrophy has been reported histomorphologically in paired samples of myocardial tissues obtained from the same patient at the time of LVAD implantation and the heart excised at transplant. The understanding of the mechanisms of recovery may contribute to strategic development for LVAD weaning and the use of LVAD as a destination therapy.

Original languageEnglish
JournalHeart Failure Clinics
Volume10
Issue number1 SUPPL.
DOIs
Publication statusPublished - Jan 2014

Fingerprint

Heart-Assist Devices
Transplants
Left Ventricular Hypertrophy
Weaning
Hypertrophy
Heart Failure

Keywords

  • Left ventricular assist device
  • Reverse remodeling
  • Unloading left ventricle

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The Pathologic Basis of Recovery. / Narula, Nupoor; Agozzino, Manuela; Gazzoli, Fabrizio; Concardi, Monica; Pagani, Francesco; Favalli, Valentina; Kodama, Takahide; Mazzola, Alessandro; D'Armini, Andrea M.; Arbustini, Eloisa.

In: Heart Failure Clinics, Vol. 10, No. 1 SUPPL., 01.2014.

Research output: Contribution to journalArticle

@article{a1e16f002e3d4f299504859027785dc7,
title = "The Pathologic Basis of Recovery",
abstract = "More patients with end-stage heart failure are now being supported by left ventricular assist devices (LVAD) as a bridge to heart transplant. The LVAD unloads the failing heart and modifies the myocardial structure, with regression of left ventricular hypertrophy. The regression of hypertrophy has been reported histomorphologically in paired samples of myocardial tissues obtained from the same patient at the time of LVAD implantation and the heart excised at transplant. The understanding of the mechanisms of recovery may contribute to strategic development for LVAD weaning and the use of LVAD as a destination therapy.",
keywords = "Left ventricular assist device, Reverse remodeling, Unloading left ventricle",
author = "Nupoor Narula and Manuela Agozzino and Fabrizio Gazzoli and Monica Concardi and Francesco Pagani and Valentina Favalli and Takahide Kodama and Alessandro Mazzola and D'Armini, {Andrea M.} and Eloisa Arbustini",
year = "2014",
month = "1",
doi = "10.1016/j.hfc.2013.09.001",
language = "English",
volume = "10",
journal = "Heart Failure Clinics",
issn = "1551-7136",
publisher = "Elsevier Inc.",
number = "1 SUPPL.",

}

TY - JOUR

T1 - The Pathologic Basis of Recovery

AU - Narula, Nupoor

AU - Agozzino, Manuela

AU - Gazzoli, Fabrizio

AU - Concardi, Monica

AU - Pagani, Francesco

AU - Favalli, Valentina

AU - Kodama, Takahide

AU - Mazzola, Alessandro

AU - D'Armini, Andrea M.

AU - Arbustini, Eloisa

PY - 2014/1

Y1 - 2014/1

N2 - More patients with end-stage heart failure are now being supported by left ventricular assist devices (LVAD) as a bridge to heart transplant. The LVAD unloads the failing heart and modifies the myocardial structure, with regression of left ventricular hypertrophy. The regression of hypertrophy has been reported histomorphologically in paired samples of myocardial tissues obtained from the same patient at the time of LVAD implantation and the heart excised at transplant. The understanding of the mechanisms of recovery may contribute to strategic development for LVAD weaning and the use of LVAD as a destination therapy.

AB - More patients with end-stage heart failure are now being supported by left ventricular assist devices (LVAD) as a bridge to heart transplant. The LVAD unloads the failing heart and modifies the myocardial structure, with regression of left ventricular hypertrophy. The regression of hypertrophy has been reported histomorphologically in paired samples of myocardial tissues obtained from the same patient at the time of LVAD implantation and the heart excised at transplant. The understanding of the mechanisms of recovery may contribute to strategic development for LVAD weaning and the use of LVAD as a destination therapy.

KW - Left ventricular assist device

KW - Reverse remodeling

KW - Unloading left ventricle

UR - http://www.scopus.com/inward/record.url?scp=84888054972&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888054972&partnerID=8YFLogxK

U2 - 10.1016/j.hfc.2013.09.001

DO - 10.1016/j.hfc.2013.09.001

M3 - Article

VL - 10

JO - Heart Failure Clinics

JF - Heart Failure Clinics

SN - 1551-7136

IS - 1 SUPPL.

ER -