The pathologist's view point. Part I - Indolent lymphomas

S. A. Pileri, S. Ascani, E. Sabattini, G. Fraternali-Orcioni, S. Poggi, M. Piccioli, P. P. Piccaluga, B. Gamberi, P. L. Zinzani, L. Leoncini, B. Falini

Research output: Contribution to journalArticle

Abstract

Background and Objectives. The REAL/WHO classification constitutes a new tool for the better understanding and treatment of malignant lymphomas. The authors focus on the key features of B-cell lymphomas with an indolent behavior, aiming to contribute to the cross-talk between pathologists and clinicians. Data Sources and Methods. Each lymphoma entity is analyzed on the basis of the most representative contributions in the literature and the authors' experience gained in studying more than 20,000 lymphoid tumors over a 20-year period. Results. Guidelines for diagnosis and areas of interest for future clinico-pathologic studies are identified and discussed. Within this context, selected data obtained by the application of novel markers are presented. Interpreation and Conclusions. The present knowledge and organization of malignant lymphomas now make the development of tailored therapies a feasible goal.

Original languageEnglish
Pages (from-to)1291-1307
Number of pages17
JournalHaematologica
Volume85
Issue number12
Publication statusPublished - 2000

Keywords

  • Behavior
  • Genotype
  • Indolent lymphoma
  • Morphology
  • Phenotype

ASJC Scopus subject areas

  • Hematology

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    Pileri, S. A., Ascani, S., Sabattini, E., Fraternali-Orcioni, G., Poggi, S., Piccioli, M., Piccaluga, P. P., Gamberi, B., Zinzani, P. L., Leoncini, L., & Falini, B. (2000). The pathologist's view point. Part I - Indolent lymphomas. Haematologica, 85(12), 1291-1307.