The pathology of the ulnar nerve in acromegaly

Alberto Tagliafico, Eugenia Resmini, Raffaella Nizzo, Lorenzo E. Derchi, Francesco Minuto, Massimo Giusti, Carlo Martinoli, Diego Ferone

Research output: Contribution to journalArticlepeer-review


Context: Acromegalic patients may complain of sensory disturbances in their hands. Cubital tunnel syndrome, the ulnar nerve neuropathy at the cubital tunnel (UCT), in acromegalic patients has never been reported. Objective: To describe and assess the prevalence of UCT in acromegalic patients and the effects of 1 year of therapy on UCT. Patients: We examined prospectively 37 acromegalic patients with no history of polyneuropathy, acute trauma at the elbow, no diabetes or hypothyroidism with clinical examination, nerve conduction studies (NCS), and high-resolution ultrasound (US). A control group was made by 50 volunteers. The local ethics committee approved the study and written informed consent was obtained from all subjects involved in the study. Intervention: Clinical history, physical examination, NCS, and US were used to diagnose UCT at the beginning of the study and after 1 year. Results: In 8 of 37 patients, a diagnosis of UCT was made at the beginning of the study reflecting a prevalence of 21%. After 1 year, 5 of 8 (62.5 %) patients reported clinical and NCS improvements and evident US reduction of nerve cross-sectional area (CSA; 16.7!+2.9 mm2 vs 12.2 ± 3.1 mm2; P2 vs 11.1 ± 2.3 mm2; P

Original languageEnglish
Pages (from-to)369-373
Number of pages5
JournalEuropean Journal of Endocrinology
Issue number4
Publication statusPublished - Oct 2008

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)


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