The pathophysiological relevance of the iNKT cell/mononuclear phagocyte crosstalk in tissues

Research output: Contribution to journalArticle

Abstract

CD1d-restricted Natural Killer T (NKT) cells are regarded as sentinels of tissue integrity by sensing local cell stress and damage. This occurs via recognition of CD1d-restricted lipid antigens, generated by stress-related metabolic changes, and stimulation by inflammatory cytokines, such as IL-12 and IL-18. Increasing evidence suggest that this occurs mainly upon NKT cell interaction with CD1d-expressing cells of the Mononuclear Phagocytic System, i.e., monocytes, macrophages and DCs, which patrol parenchymatous organs and mucosae to maintain tissue homeostasis and immune surveillance. In this review, we discuss critical examples of this crosstalk, presenting the known underlying mechanisms and their effects on both cell types and the environment, and suggest that the interaction with CD1d-expressing mononuclear phagocytes in tissues is the fundamental job of NKT cells.? © 2007 - 2018 Frontiers Media S.A. All Rights Reserved.
Original languageEnglish
Article number2375
JournalFrontiers in Immunology
Volume9
DOIs
Publication statusPublished - 2018

Fingerprint

Natural Killer T-Cells
Phagocytes
Interleukin-18
Interleukin-12
Cell Communication
Monocytes
Mucous Membrane
Homeostasis
Macrophages
Cytokines
Lipids
Antigens

Cite this

@article{e4f0814ab856497c9296aa18c3e344aa,
title = "The pathophysiological relevance of the iNKT cell/mononuclear phagocyte crosstalk in tissues",
abstract = "CD1d-restricted Natural Killer T (NKT) cells are regarded as sentinels of tissue integrity by sensing local cell stress and damage. This occurs via recognition of CD1d-restricted lipid antigens, generated by stress-related metabolic changes, and stimulation by inflammatory cytokines, such as IL-12 and IL-18. Increasing evidence suggest that this occurs mainly upon NKT cell interaction with CD1d-expressing cells of the Mononuclear Phagocytic System, i.e., monocytes, macrophages and DCs, which patrol parenchymatous organs and mucosae to maintain tissue homeostasis and immune surveillance. In this review, we discuss critical examples of this crosstalk, presenting the known underlying mechanisms and their effects on both cell types and the environment, and suggest that the interaction with CD1d-expressing mononuclear phagocytes in tissues is the fundamental job of NKT cells.? {\circledC} 2007 - 2018 Frontiers Media S.A. All Rights Reserved.",
author = "F Cortesi and G Delfanti and G Casorati and P Dellabona",
year = "2018",
doi = "10.3389/fimmu.2018.02375",
language = "English",
volume = "9",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media S.A.",

}

TY - JOUR

T1 - The pathophysiological relevance of the iNKT cell/mononuclear phagocyte crosstalk in tissues

AU - Cortesi, F

AU - Delfanti, G

AU - Casorati, G

AU - Dellabona, P

PY - 2018

Y1 - 2018

N2 - CD1d-restricted Natural Killer T (NKT) cells are regarded as sentinels of tissue integrity by sensing local cell stress and damage. This occurs via recognition of CD1d-restricted lipid antigens, generated by stress-related metabolic changes, and stimulation by inflammatory cytokines, such as IL-12 and IL-18. Increasing evidence suggest that this occurs mainly upon NKT cell interaction with CD1d-expressing cells of the Mononuclear Phagocytic System, i.e., monocytes, macrophages and DCs, which patrol parenchymatous organs and mucosae to maintain tissue homeostasis and immune surveillance. In this review, we discuss critical examples of this crosstalk, presenting the known underlying mechanisms and their effects on both cell types and the environment, and suggest that the interaction with CD1d-expressing mononuclear phagocytes in tissues is the fundamental job of NKT cells.? © 2007 - 2018 Frontiers Media S.A. All Rights Reserved.

AB - CD1d-restricted Natural Killer T (NKT) cells are regarded as sentinels of tissue integrity by sensing local cell stress and damage. This occurs via recognition of CD1d-restricted lipid antigens, generated by stress-related metabolic changes, and stimulation by inflammatory cytokines, such as IL-12 and IL-18. Increasing evidence suggest that this occurs mainly upon NKT cell interaction with CD1d-expressing cells of the Mononuclear Phagocytic System, i.e., monocytes, macrophages and DCs, which patrol parenchymatous organs and mucosae to maintain tissue homeostasis and immune surveillance. In this review, we discuss critical examples of this crosstalk, presenting the known underlying mechanisms and their effects on both cell types and the environment, and suggest that the interaction with CD1d-expressing mononuclear phagocytes in tissues is the fundamental job of NKT cells.? © 2007 - 2018 Frontiers Media S.A. All Rights Reserved.

U2 - 10.3389/fimmu.2018.02375

DO - 10.3389/fimmu.2018.02375

M3 - Article

VL - 9

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

M1 - 2375

ER -