Abstract
| Original language | English |
|---|---|
| Article number | 2375 |
| Journal | Frontiers in Immunology |
| Volume | 9 |
| DOIs | |
| Publication status | Published - 2018 |
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The pathophysiological relevance of the iNKT cell/mononuclear phagocyte crosstalk in tissues. / Cortesi, F; Delfanti, G; Casorati, G; Dellabona, P.
In: Frontiers in Immunology, Vol. 9, 2375, 2018.Research output: Contribution to journal › Article
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TY - JOUR
T1 - The pathophysiological relevance of the iNKT cell/mononuclear phagocyte crosstalk in tissues
AU - Cortesi, F
AU - Delfanti, G
AU - Casorati, G
AU - Dellabona, P
PY - 2018
Y1 - 2018
N2 - CD1d-restricted Natural Killer T (NKT) cells are regarded as sentinels of tissue integrity by sensing local cell stress and damage. This occurs via recognition of CD1d-restricted lipid antigens, generated by stress-related metabolic changes, and stimulation by inflammatory cytokines, such as IL-12 and IL-18. Increasing evidence suggest that this occurs mainly upon NKT cell interaction with CD1d-expressing cells of the Mononuclear Phagocytic System, i.e., monocytes, macrophages and DCs, which patrol parenchymatous organs and mucosae to maintain tissue homeostasis and immune surveillance. In this review, we discuss critical examples of this crosstalk, presenting the known underlying mechanisms and their effects on both cell types and the environment, and suggest that the interaction with CD1d-expressing mononuclear phagocytes in tissues is the fundamental job of NKT cells.? © 2007 - 2018 Frontiers Media S.A. All Rights Reserved.
AB - CD1d-restricted Natural Killer T (NKT) cells are regarded as sentinels of tissue integrity by sensing local cell stress and damage. This occurs via recognition of CD1d-restricted lipid antigens, generated by stress-related metabolic changes, and stimulation by inflammatory cytokines, such as IL-12 and IL-18. Increasing evidence suggest that this occurs mainly upon NKT cell interaction with CD1d-expressing cells of the Mononuclear Phagocytic System, i.e., monocytes, macrophages and DCs, which patrol parenchymatous organs and mucosae to maintain tissue homeostasis and immune surveillance. In this review, we discuss critical examples of this crosstalk, presenting the known underlying mechanisms and their effects on both cell types and the environment, and suggest that the interaction with CD1d-expressing mononuclear phagocytes in tissues is the fundamental job of NKT cells.? © 2007 - 2018 Frontiers Media S.A. All Rights Reserved.
U2 - 10.3389/fimmu.2018.02375
DO - 10.3389/fimmu.2018.02375
M3 - Article
VL - 9
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
M1 - 2375
ER -