Natural killer (NK) cells are an essential component of innate immunity that can rapidly detect and respond to malignant or infected cells. Chemokines play important roles in directing immune responses by controlling tissue homing, retention, and activation of immune cells. Although some chemokines can promote tumor growth and metastasis, others are responsible for extensive infiltration of lymphocytes, thus resulting in a protective anti-tumor immune response. Here, we summarize discoveries that have revealed the role of specific chemokines in regulating the function of NK cells during inflammation, infection, and malignancies.
|Number of pages||14|
|Journal||Critical Reviews in Oncogenesis|
|Publication status||Published - 2014|
- NK cell
- Tissue homing
ASJC Scopus subject areas
- Cancer Research