The Pathophysiological Role of Neutrophil Extracellular Traps in Inflammatory Diseases

Aldo Bonaventura, Luca Liberale, Federico Carbone, Alessandra Vecchié, Candela Diaz-Cañestro, Giovanni G. Camici, Fabrizio Montecucco, Franco Dallegri

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

Neutrophil pathogen-killing mechanism termed neutrophil extracellular traps (NETs) has been recently identified. NETs consist of chromatin and histones along with serine proteases and myeloperoxidase and are induced by a great variety of infectious and non-infectious stimuli. NETosis is a kind of programmed neutrophil death characterized by chromatin decondensation and release of nuclear granular contents, mainly driven by peptidylarginine deiminase 4 citrullination of histones. Although classically related to the protection against infectious pathogens, nowadays NETs have been described as a player of several pathophysiological processes. Neutrophil dysregulation has been demonstrated in the pathogenesis of most representative vascular diseases, such as acute coronary syndrome, stroke and venous thrombosis. Indeed, NETs have been identified within atherosclerotic lesions and arterial thrombi in both human beings and animal models. Moreover, an imbalance in this mechanism has been proposed as a critical source of modified and/or externalized autoantigens in autoimmune and inflammatory diseases. Finally, an update on the role of NETs in the pathogenesis of cancer has been included. In the present review, based on papers released on PubMed and MEDLINE up to July 2017, we point to update the knowledge on NETs, from their structure to their roles in infectious diseases as well as in cardiovascular diseases, autoimmunity, metabolic disorders and cancer, with a look to future perspectives and therapeutic opportunities.

Original languageEnglish
Pages (from-to)6-27
Number of pages22
JournalThrombosis and Haemostasis
Volume118
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Neutrophils
Histones
Chromatin
Coronary Thrombosis
Autoantigens
Serine Proteases
Acute Coronary Syndrome
Autoimmunity
Vascular Diseases
PubMed
MEDLINE
Venous Thrombosis
Peroxidase
Autoimmune Diseases
Communicable Diseases
Extracellular Traps
Neoplasms
Thrombosis
Cardiovascular Diseases
Animal Models

Keywords

  • autoimmune diseases
  • cancer
  • infectious diseases
  • metabolic disorders
  • NETs

ASJC Scopus subject areas

  • Hematology

Cite this

Bonaventura, A., Liberale, L., Carbone, F., Vecchié, A., Diaz-Cañestro, C., Camici, G. G., ... Dallegri, F. (2018). The Pathophysiological Role of Neutrophil Extracellular Traps in Inflammatory Diseases. Thrombosis and Haemostasis, 118(1), 6-27. https://doi.org/10.1160/TH17-09-0630

The Pathophysiological Role of Neutrophil Extracellular Traps in Inflammatory Diseases. / Bonaventura, Aldo; Liberale, Luca; Carbone, Federico; Vecchié, Alessandra; Diaz-Cañestro, Candela; Camici, Giovanni G.; Montecucco, Fabrizio; Dallegri, Franco.

In: Thrombosis and Haemostasis, Vol. 118, No. 1, 01.01.2018, p. 6-27.

Research output: Contribution to journalReview article

Bonaventura, A, Liberale, L, Carbone, F, Vecchié, A, Diaz-Cañestro, C, Camici, GG, Montecucco, F & Dallegri, F 2018, 'The Pathophysiological Role of Neutrophil Extracellular Traps in Inflammatory Diseases', Thrombosis and Haemostasis, vol. 118, no. 1, pp. 6-27. https://doi.org/10.1160/TH17-09-0630
Bonaventura A, Liberale L, Carbone F, Vecchié A, Diaz-Cañestro C, Camici GG et al. The Pathophysiological Role of Neutrophil Extracellular Traps in Inflammatory Diseases. Thrombosis and Haemostasis. 2018 Jan 1;118(1):6-27. https://doi.org/10.1160/TH17-09-0630
Bonaventura, Aldo ; Liberale, Luca ; Carbone, Federico ; Vecchié, Alessandra ; Diaz-Cañestro, Candela ; Camici, Giovanni G. ; Montecucco, Fabrizio ; Dallegri, Franco. / The Pathophysiological Role of Neutrophil Extracellular Traps in Inflammatory Diseases. In: Thrombosis and Haemostasis. 2018 ; Vol. 118, No. 1. pp. 6-27.
@article{e06d18690dc1473a89a20dbd3dbe1da5,
title = "The Pathophysiological Role of Neutrophil Extracellular Traps in Inflammatory Diseases",
abstract = "Neutrophil pathogen-killing mechanism termed neutrophil extracellular traps (NETs) has been recently identified. NETs consist of chromatin and histones along with serine proteases and myeloperoxidase and are induced by a great variety of infectious and non-infectious stimuli. NETosis is a kind of programmed neutrophil death characterized by chromatin decondensation and release of nuclear granular contents, mainly driven by peptidylarginine deiminase 4 citrullination of histones. Although classically related to the protection against infectious pathogens, nowadays NETs have been described as a player of several pathophysiological processes. Neutrophil dysregulation has been demonstrated in the pathogenesis of most representative vascular diseases, such as acute coronary syndrome, stroke and venous thrombosis. Indeed, NETs have been identified within atherosclerotic lesions and arterial thrombi in both human beings and animal models. Moreover, an imbalance in this mechanism has been proposed as a critical source of modified and/or externalized autoantigens in autoimmune and inflammatory diseases. Finally, an update on the role of NETs in the pathogenesis of cancer has been included. In the present review, based on papers released on PubMed and MEDLINE up to July 2017, we point to update the knowledge on NETs, from their structure to their roles in infectious diseases as well as in cardiovascular diseases, autoimmunity, metabolic disorders and cancer, with a look to future perspectives and therapeutic opportunities.",
keywords = "autoimmune diseases, cancer, infectious diseases, metabolic disorders, NETs",
author = "Aldo Bonaventura and Luca Liberale and Federico Carbone and Alessandra Vecchi{\'e} and Candela Diaz-Ca{\~n}estro and Camici, {Giovanni G.} and Fabrizio Montecucco and Franco Dallegri",
year = "2018",
month = "1",
day = "1",
doi = "10.1160/TH17-09-0630",
language = "English",
volume = "118",
pages = "6--27",
journal = "Thrombosis and Haemostasis",
issn = "0340-6245",
publisher = "Schattauer GmbH",
number = "1",

}

TY - JOUR

T1 - The Pathophysiological Role of Neutrophil Extracellular Traps in Inflammatory Diseases

AU - Bonaventura, Aldo

AU - Liberale, Luca

AU - Carbone, Federico

AU - Vecchié, Alessandra

AU - Diaz-Cañestro, Candela

AU - Camici, Giovanni G.

AU - Montecucco, Fabrizio

AU - Dallegri, Franco

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Neutrophil pathogen-killing mechanism termed neutrophil extracellular traps (NETs) has been recently identified. NETs consist of chromatin and histones along with serine proteases and myeloperoxidase and are induced by a great variety of infectious and non-infectious stimuli. NETosis is a kind of programmed neutrophil death characterized by chromatin decondensation and release of nuclear granular contents, mainly driven by peptidylarginine deiminase 4 citrullination of histones. Although classically related to the protection against infectious pathogens, nowadays NETs have been described as a player of several pathophysiological processes. Neutrophil dysregulation has been demonstrated in the pathogenesis of most representative vascular diseases, such as acute coronary syndrome, stroke and venous thrombosis. Indeed, NETs have been identified within atherosclerotic lesions and arterial thrombi in both human beings and animal models. Moreover, an imbalance in this mechanism has been proposed as a critical source of modified and/or externalized autoantigens in autoimmune and inflammatory diseases. Finally, an update on the role of NETs in the pathogenesis of cancer has been included. In the present review, based on papers released on PubMed and MEDLINE up to July 2017, we point to update the knowledge on NETs, from their structure to their roles in infectious diseases as well as in cardiovascular diseases, autoimmunity, metabolic disorders and cancer, with a look to future perspectives and therapeutic opportunities.

AB - Neutrophil pathogen-killing mechanism termed neutrophil extracellular traps (NETs) has been recently identified. NETs consist of chromatin and histones along with serine proteases and myeloperoxidase and are induced by a great variety of infectious and non-infectious stimuli. NETosis is a kind of programmed neutrophil death characterized by chromatin decondensation and release of nuclear granular contents, mainly driven by peptidylarginine deiminase 4 citrullination of histones. Although classically related to the protection against infectious pathogens, nowadays NETs have been described as a player of several pathophysiological processes. Neutrophil dysregulation has been demonstrated in the pathogenesis of most representative vascular diseases, such as acute coronary syndrome, stroke and venous thrombosis. Indeed, NETs have been identified within atherosclerotic lesions and arterial thrombi in both human beings and animal models. Moreover, an imbalance in this mechanism has been proposed as a critical source of modified and/or externalized autoantigens in autoimmune and inflammatory diseases. Finally, an update on the role of NETs in the pathogenesis of cancer has been included. In the present review, based on papers released on PubMed and MEDLINE up to July 2017, we point to update the knowledge on NETs, from their structure to their roles in infectious diseases as well as in cardiovascular diseases, autoimmunity, metabolic disorders and cancer, with a look to future perspectives and therapeutic opportunities.

KW - autoimmune diseases

KW - cancer

KW - infectious diseases

KW - metabolic disorders

KW - NETs

UR - http://www.scopus.com/inward/record.url?scp=85049384094&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049384094&partnerID=8YFLogxK

U2 - 10.1160/TH17-09-0630

DO - 10.1160/TH17-09-0630

M3 - Review article

AN - SCOPUS:85049384094

VL - 118

SP - 6

EP - 27

JO - Thrombosis and Haemostasis

JF - Thrombosis and Haemostasis

SN - 0340-6245

IS - 1

ER -