The Pavia approach to clinical protein analysis

G. Merlini, S. Marciano, C. Gasparro, I. Zorzoli, T. Bosoni, R. Moratti

Research output: Contribution to journalArticlepeer-review


The protein chemistry laboratory of the Pavia University Hospital is specialized in the study of monoclonal components in body fluids. It is closely connected with the research laboratory devoted to the structural and functional study of pathogenic proteins and with the Clinical Chemistry Central Laboratory. The analyses are performed on specific medical request. The analytical approach is mainly based on analysis of patient's serum and urine by high-resolution agarose gel electrophoresis and immunofixation with the possible addition of the quantification of specific proteins. The interpretation of the protein pattern and the final reporting result from the integration of the laboratory data with the clinical information. This labor-intensive approach requires skills in the performance of protein analysis and in the interpretation/referral phase, as well as close communication with the attending physician.

Original languageEnglish
Pages (from-to)1025-1028
Number of pages4
JournalClinical Chemistry and Laboratory Medicine
Issue number11
Publication statusPublished - 2001


  • High-resolution agarose gel electrophoresis
  • Immunofixation
  • Monoclonal gammopathies
  • Protein analysis

ASJC Scopus subject areas

  • Clinical Biochemistry


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