TY - JOUR
T1 - The PE multigene family
T2 - A 'molecular mantra' for mycobacteria
AU - Brennan, Michael J.
AU - Delogu, Giovanni
PY - 2002/5/1
Y1 - 2002/5/1
N2 - The PE multigene family of Mycobacterium tuberculosis is remarkable in that it is composed of approximately 100 highly homologous genes that are found only in mycobacteria. Early evidence suggests that proteins encoded by certain members of this gene family could be present in the mycobacterial cell wall, impact antigen-presentation pathways and the ensuing host immune responses, and also provide a mechanism for generating antigenic diversity in mycobacteria.
AB - The PE multigene family of Mycobacterium tuberculosis is remarkable in that it is composed of approximately 100 highly homologous genes that are found only in mycobacteria. Early evidence suggests that proteins encoded by certain members of this gene family could be present in the mycobacterial cell wall, impact antigen-presentation pathways and the ensuing host immune responses, and also provide a mechanism for generating antigenic diversity in mycobacteria.
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U2 - 10.1016/S0966-842X(02)02335-1
DO - 10.1016/S0966-842X(02)02335-1
M3 - Article
C2 - 11973159
AN - SCOPUS:0036568632
VL - 10
SP - 246
EP - 249
JO - Trends in Microbiology
JF - Trends in Microbiology
SN - 0966-842X
IS - 5
ER -