The peopling of South America and the trans-Andean gene flow of the first settlers

Alberto Gómez-Carballa, Jacobo Pardo-Seco, Stefania Brandini, Alessandro Achilli, Ugo A Perego, Michael D Coble, Toni M Diegoli, Vanesa Álvarez-Iglesias, Federico Martinón-Torres, Anna Olivieri, Antonio Torroni, Antonio Salas

Research output: Contribution to journalArticle

Abstract

Genetic and archaeological data indicate that the initial Paleoindian settlers of South America followed two entry routes separated by the Andes and the Amazon rainforest. The interactions between these paths and their impact on the peopling of South America remain unclear. Analysis of genetic variation in the Peruvian Andes and regions located south of the Amazon River might provide clues on this issue. We analyzed mitochondrial DNA variation at different Andean locations and >360,000 autosomal SNPs from 28 Native American ethnic groups to evaluate different trans-Andean demographic scenarios. Our data reveal that the Peruvian Altiplano was an important enclave for early Paleoindian expansions and point to a genetic continuity in the Andes until recent times, which was only marginally affected by gene flow from the Amazonian lowlands. Genomic variation shows a good fit with the archaeological evidence, indicating that the genetic interactions between the descendants of the settlers that followed the Pacific and Atlantic routes were extremely limited.

Original languageEnglish
Pages (from-to)767-779
Number of pages13
JournalGenome Research
Volume28
Issue number6
DOIs
Publication statusPublished - Jun 2018

Fingerprint

Gene Flow
South America
North American Indians
Mitochondrial DNA
Ethnic Groups
Rivers
Single Nucleotide Polymorphism
Demography
Rainforest

Keywords

  • Archaeology
  • Chromosomes, Human, Y/genetics
  • DNA, Mitochondrial/genetics
  • Ethnic Groups/genetics
  • Gene Flow/genetics
  • Genetic Variation
  • Genetics, Population
  • Haplotypes
  • Humans
  • Mitochondria/genetics
  • Polymorphism, Single Nucleotide/genetics
  • South America

Cite this

Gómez-Carballa, A., Pardo-Seco, J., Brandini, S., Achilli, A., Perego, U. A., Coble, M. D., ... Salas, A. (2018). The peopling of South America and the trans-Andean gene flow of the first settlers. Genome Research, 28(6), 767-779. https://doi.org/10.1101/gr.234674.118

The peopling of South America and the trans-Andean gene flow of the first settlers. / Gómez-Carballa, Alberto; Pardo-Seco, Jacobo; Brandini, Stefania; Achilli, Alessandro; Perego, Ugo A; Coble, Michael D; Diegoli, Toni M; Álvarez-Iglesias, Vanesa; Martinón-Torres, Federico; Olivieri, Anna; Torroni, Antonio; Salas, Antonio.

In: Genome Research, Vol. 28, No. 6, 06.2018, p. 767-779.

Research output: Contribution to journalArticle

Gómez-Carballa, A, Pardo-Seco, J, Brandini, S, Achilli, A, Perego, UA, Coble, MD, Diegoli, TM, Álvarez-Iglesias, V, Martinón-Torres, F, Olivieri, A, Torroni, A & Salas, A 2018, 'The peopling of South America and the trans-Andean gene flow of the first settlers', Genome Research, vol. 28, no. 6, pp. 767-779. https://doi.org/10.1101/gr.234674.118
Gómez-Carballa A, Pardo-Seco J, Brandini S, Achilli A, Perego UA, Coble MD et al. The peopling of South America and the trans-Andean gene flow of the first settlers. Genome Research. 2018 Jun;28(6):767-779. https://doi.org/10.1101/gr.234674.118
Gómez-Carballa, Alberto ; Pardo-Seco, Jacobo ; Brandini, Stefania ; Achilli, Alessandro ; Perego, Ugo A ; Coble, Michael D ; Diegoli, Toni M ; Álvarez-Iglesias, Vanesa ; Martinón-Torres, Federico ; Olivieri, Anna ; Torroni, Antonio ; Salas, Antonio. / The peopling of South America and the trans-Andean gene flow of the first settlers. In: Genome Research. 2018 ; Vol. 28, No. 6. pp. 767-779.
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