The perilesional skin in vitiligo: A colorimetric in vivo study of 25 patients

Valeria Brazzelli, F. Muzio, M. Antoninetti, S. Villani, F. Donadini, A. Altomare, G. Borroni

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The aim of this work was to study in vivo the perilesional skin in vitiligo with a colorimetric method. Methods: Twenty-five patients affected by vitiligo were included. For each patient, three different areas were considered: the lesional, the perilesional and the normal skin as far as 5cm from the nearest vitiligo spot. Skin pigmentation measurements were performed with a chromameter. Results: The results showed that luminance L* decreased significantly in relation to increasing distance from the vitiligo spot. As expected, L* in the vitiligo spot was significantly higher than in the perilesional (P <0.0001) and normal skin (P <0.0001). There was a small difference in L* between normal skin as far as 5cm from the nearest vitiligo spot and perilesional skin. In contrast, the pigmentation index (b*) gradually increased from lesional to perilesional to normal skin. Furthermore, the comparison of the b* value between the normal skin as far as 5cm from the nearest vitiligo spot was higher than perilesional skin and it was statistically significant (P <0.0001). Conclusion: Our results in vivo underline that the perilesional skin near the vitiligo spot is lighter than normal skin as far as 5 cm from the vitiligo spot.

Original languageEnglish
Pages (from-to)314-317
Number of pages4
JournalPhotodermatology Photoimmunology and Photomedicine
Volume24
Issue number6
DOIs
Publication statusPublished - 2008

Keywords

  • Colorimetry
  • Non-invasive methods
  • Perilesional skin
  • Vitiligo

ASJC Scopus subject areas

  • Dermatology
  • Immunology and Allergy
  • Immunology
  • Radiology Nuclear Medicine and imaging

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