The persistency of high levels of pSTAT3 expression in circulating CD4+ T cells from CIS patients favors the early conversion to clinically defined multiple sclerosis

Giovanni Frisullo; Viviana Nociti; Raffaele Iorio; Agata Katia Patanella; Alessandro Marti; Massimiliano Mirabella; Pietro Attilio Tonali; Anna Paola Batocchi

doi:10.1016/j.jneuroim.2008.09.003

The persistency of high levels of pSTAT3 expression in circulating CD4+ T cells from CIS patients favors the early conversion to clinically defined multiple sclerosis

Giovanni Frisullo, Viviana Nociti, Raffaele Iorio, Agata Katia Patanella, Alessandro Marti, Massimiliano Mirabella, Pietro Attilio Tonali, Anna Paola Batocchi

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

Not all patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) develop clinically defined MS (CDMS). At first clinical event we observed increased production of IL17, IFNγ and IL10 by peripheral blood mononuclear cells from patients with CIS that remained high in remission. In CD4+ T cells pSTAT3 expression was higher in patients who subsequently converted to CDMS than in patients who did not and controls. The persistency of high levels of pSTAT3 in circulating CD4+ T cells from CIS patients after the first clinical event may favor the early conversion to CDMS.

Original language	English
Pages (from-to)	126-134
Number of pages	9
Journal	Journal of Neuroimmunology
Volume	205
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2008.09.003
Publication status	Published - Dec 15 2008

Keywords

Clinically isolated syndrome
IFNγ
IL17
STAT1
STAT3
T-bet

ASJC Scopus subject areas

Immunology
Clinical Neurology
Immunology and Allergy
Neurology

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Frisullo, G., Nociti, V., Iorio, R., Patanella, A. K., Marti, A., Mirabella, M., Tonali, P. A., & Batocchi, A. P. (2008). The persistency of high levels of pSTAT3 expression in circulating CD4+ T cells from CIS patients favors the early conversion to clinically defined multiple sclerosis. Journal of Neuroimmunology, 205(1-2), 126-134. https://doi.org/10.1016/j.jneuroim.2008.09.003

The persistency of high levels of pSTAT3 expression in circulating CD4+ T cells from CIS patients favors the early conversion to clinically defined multiple sclerosis. / Frisullo, Giovanni; Nociti, Viviana; Iorio, Raffaele; Patanella, Agata Katia; Marti, Alessandro; Mirabella, Massimiliano; Tonali, Pietro Attilio; Batocchi, Anna Paola.

In: Journal of Neuroimmunology, Vol. 205, No. 1-2, 15.12.2008, p. 126-134.

Research output: Contribution to journal › Article › peer-review

Frisullo, G, Nociti, V, Iorio, R, Patanella, AK, Marti, A, Mirabella, M, Tonali, PA & Batocchi, AP 2008, 'The persistency of high levels of pSTAT3 expression in circulating CD4+ T cells from CIS patients favors the early conversion to clinically defined multiple sclerosis', Journal of Neuroimmunology, vol. 205, no. 1-2, pp. 126-134. https://doi.org/10.1016/j.jneuroim.2008.09.003

Frisullo, Giovanni ; Nociti, Viviana ; Iorio, Raffaele ; Patanella, Agata Katia ; Marti, Alessandro ; Mirabella, Massimiliano ; Tonali, Pietro Attilio ; Batocchi, Anna Paola. / The persistency of high levels of pSTAT3 expression in circulating CD4+ T cells from CIS patients favors the early conversion to clinically defined multiple sclerosis. In: Journal of Neuroimmunology. 2008 ; Vol. 205, No. 1-2. pp. 126-134.

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abstract = "Not all patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) develop clinically defined MS (CDMS). At first clinical event we observed increased production of IL17, IFNγ and IL10 by peripheral blood mononuclear cells from patients with CIS that remained high in remission. In CD4+ T cells pSTAT3 expression was higher in patients who subsequently converted to CDMS than in patients who did not and controls. The persistency of high levels of pSTAT3 in circulating CD4+ T cells from CIS patients after the first clinical event may favor the early conversion to CDMS.",

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