The persistency of high levels of pSTAT3 expression in circulating CD4+ T cells from CIS patients favors the early conversion to clinically defined multiple sclerosis

Giovanni Frisullo, Viviana Nociti, Raffaele Iorio, Agata Katia Patanella, Alessandro Marti, Massimiliano Mirabella, Pietro Attilio Tonali, Anna Paola Batocchi

Research output: Contribution to journalArticlepeer-review

Abstract

Not all patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) develop clinically defined MS (CDMS). At first clinical event we observed increased production of IL17, IFNγ and IL10 by peripheral blood mononuclear cells from patients with CIS that remained high in remission. In CD4+ T cells pSTAT3 expression was higher in patients who subsequently converted to CDMS than in patients who did not and controls. The persistency of high levels of pSTAT3 in circulating CD4+ T cells from CIS patients after the first clinical event may favor the early conversion to CDMS.

Original languageEnglish
Pages (from-to)126-134
Number of pages9
JournalJournal of Neuroimmunology
Volume205
Issue number1-2
DOIs
Publication statusPublished - Dec 15 2008

Keywords

  • Clinically isolated syndrome
  • IFNγ
  • IL17
  • STAT1
  • STAT3
  • T-bet

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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