TY - JOUR
T1 - The persistency of high levels of pSTAT3 expression in circulating CD4+ T cells from CIS patients favors the early conversion to clinically defined multiple sclerosis
AU - Frisullo, Giovanni
AU - Nociti, Viviana
AU - Iorio, Raffaele
AU - Patanella, Agata Katia
AU - Marti, Alessandro
AU - Mirabella, Massimiliano
AU - Tonali, Pietro Attilio
AU - Batocchi, Anna Paola
PY - 2008/12/15
Y1 - 2008/12/15
N2 - Not all patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) develop clinically defined MS (CDMS). At first clinical event we observed increased production of IL17, IFNγ and IL10 by peripheral blood mononuclear cells from patients with CIS that remained high in remission. In CD4+ T cells pSTAT3 expression was higher in patients who subsequently converted to CDMS than in patients who did not and controls. The persistency of high levels of pSTAT3 in circulating CD4+ T cells from CIS patients after the first clinical event may favor the early conversion to CDMS.
AB - Not all patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) develop clinically defined MS (CDMS). At first clinical event we observed increased production of IL17, IFNγ and IL10 by peripheral blood mononuclear cells from patients with CIS that remained high in remission. In CD4+ T cells pSTAT3 expression was higher in patients who subsequently converted to CDMS than in patients who did not and controls. The persistency of high levels of pSTAT3 in circulating CD4+ T cells from CIS patients after the first clinical event may favor the early conversion to CDMS.
KW - Clinically isolated syndrome
KW - IFNγ
KW - IL17
KW - STAT1
KW - STAT3
KW - T-bet
UR - http://www.scopus.com/inward/record.url?scp=56349095790&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=56349095790&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2008.09.003
DO - 10.1016/j.jneuroim.2008.09.003
M3 - Article
C2 - 18926576
AN - SCOPUS:56349095790
VL - 205
SP - 126
EP - 134
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -