The pharmacokinetic profile of clofoctol in rat plasma and tissues after oral and rectal administration

M. G. Alessandri, M. Ducci, V. Scalori, R. Danesi, M. Del Tacca, M. C. Bernardini, L. Mazzanti

Research output: Contribution to journalArticlepeer-review

Abstract

The pharmacokinetics of clofoctol was investigated in rat plasma and tissues after both oral and rectal treatment at a single dose of 300 mg/kg. After oral administration the plasmatic peak was 2.12 ± 0.92 μg/ml, occurring at the 90th min, with T/2 of 121.45 ± 23.41 min. After rectal administration a plasmatic peak of 1.97 ± 0.61 μg/ml was reached at the 20th min with T/2 of 41.07 ± 12.30 min. The kinetic profile of the drug in tissues exhibited a pattern similar to that in the plasma, since the maximal peak of clofoctol in tissues following rectal administration occurred before that obtained after oral administration. Tissue concentrations significantly higher than plasmatic ones were obtained through both administration routes. The present results indicate that clofoctol is well absorbed after both oral and rectal administration; however rectal treatment produces more rapid absorption and elimination compared with oral treatment.

Original languageEnglish
Pages (from-to)343-347
Number of pages5
JournalDrugs under Experimental and Clinical Research
Volume12
Issue number4
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology (medical)
  • Pharmacology
  • Drug Discovery

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