The pharmacokinetics and immunosuppressive response of tacrolimus in paediatric renal transplant recipients

Giovanni Montini, Francesca Ujka, Cristina Varagnolo, Luciana Ghio, Fabrizio Ginevri, Luisa Murer, Basile S. Thafam, Carla Carasi, Graziella Zacchello, Mario Plebani

Research output: Contribution to journalArticlepeer-review

Abstract

The aims of our trial were to study the pharmacokinetics of tacrolimus in paediatric kidney transplant recipients. The study comprised 25 patients (median age 13 years, range 2-20 years) followed for 12 months; five pharmacokinetics profiles (within the first and second week and after 1 month, 6 months and 12 months) were obtained. Patients were divided into two groups: six children 2 and 64.0±15.2 ml/ min per 1.73 m2 body surface area, respectively. Tacrolimus trough levels were 7.8±1.9 ng/ml and 7.3±2.5 ng/ml. The area under the concentration-time curve for 0 h to 12 h (AUC0-12) normalised to a dose of 0.15 mg/kg, increased with time from the kidney transplantation and stabilised after the 6th month post-transplantation. During the first month after transplantation the normalised tacrolimus concentration-time profiles were significantly greater in the older children (P

Original languageEnglish
Pages (from-to)719-724
Number of pages6
JournalPediatric Nephrology
Volume21
Issue number5
DOIs
Publication statusPublished - May 2006

Keywords

  • Acute rejection
  • Children
  • Chronic rejection
  • Kidney transplantation
  • Pharmacokinetics
  • Tacrolimus

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

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