The pharmacokinetics of aztreonam and penetration into the bronchial secretions of critically ill patients

A. Boccazzi, M. Langer, M. Mandelli, A. M. Ranzi, R. Urso

Research output: Contribution to journalArticle

Abstract

The pharmacokinetics of aztreonam were studied in ten critically ill intubated patients with lower respiratory tract infections. Serum and urinary concentrations of the drug and its penetration into bronchial secretions after a 2-g intravenous bolus were measured. Using a two-compartment linear model a terminal half-life of 1.87 + 0.46 h was determined. No interpatient differences were found for half-life values, AUC or volume of distribution, except in the case of one obese patient. The greatest variability was observed in the clearance values, and in particular the extrarenal clearance which ranged from 0.3 to 9.6 l/h. Maximum concentrations in bronchial secretions were reached very quickly in the 2 h after drug administration, with a range of 4.8-18.7 mg/l. No accumulation of aztreonam after repeated doses was detected.

Original languageEnglish
Pages (from-to)401-407
Number of pages7
JournalJournal of Antimicrobial Chemotherapy
Volume23
Issue number3
Publication statusPublished - 1989

Fingerprint

Aztreonam
Pharmacokinetics
Secretion
Clearance
Critical Illness
Penetration
Half-Life
Drugs
Compartment Model
Respiratory Tract Infections
Pharmaceutical Preparations
Area Under Curve
Infection
Linear Models
Linear Model
Dose
Serum
Range of data
Life
Half-life

ASJC Scopus subject areas

  • Microbiology
  • Pharmacology
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

The pharmacokinetics of aztreonam and penetration into the bronchial secretions of critically ill patients. / Boccazzi, A.; Langer, M.; Mandelli, M.; Ranzi, A. M.; Urso, R.

In: Journal of Antimicrobial Chemotherapy, Vol. 23, No. 3, 1989, p. 401-407.

Research output: Contribution to journalArticle

Boccazzi, A, Langer, M, Mandelli, M, Ranzi, AM & Urso, R 1989, 'The pharmacokinetics of aztreonam and penetration into the bronchial secretions of critically ill patients', Journal of Antimicrobial Chemotherapy, vol. 23, no. 3, pp. 401-407.
Boccazzi, A. ; Langer, M. ; Mandelli, M. ; Ranzi, A. M. ; Urso, R. / The pharmacokinetics of aztreonam and penetration into the bronchial secretions of critically ill patients. In: Journal of Antimicrobial Chemotherapy. 1989 ; Vol. 23, No. 3. pp. 401-407.
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