The phenotype of Floating-Harbor syndrome: Clinical characterization of 52 individuals with mutations in exon 34 of SRCAP

Sarah M. Nikkel, Andrew Dauber, Sonja De Munnik, Meghan Connolly, Rebecca L. Hood, Oana Caluseriu, Jane Hurst, Usha Kini, Malgorzata J M Nowaczyk, Alexandra Afenjar, Beate Albrecht, Judith E. Allanson, Paolo Balestri, Tawfeg Ben-Omran, Francesco Brancati, Isabel Cordeiro, Bruna Santos Da Cunha, Louisa A. Delaney, Anne Destrée, David FitzpatrickFrancesca Forzano, Neeti Ghali, Greta Gillies, Katerina Harwood, Yvonne M C Hendriks, Delphine Héron, Alexander Hoischen, Engela Magdalena Honey, Lies H. Hoefsloot, Jennifer Ibrahim, Claire M. Jacob, Sarina G. Kant, Chong Ae Kim, Edwin P. Kirk, Nine V A M Knoers, Didier Lacombe, Chung Lee, Ivan F M Lo, Luiza S. Lucas, Francesca Mari, Veronica Mericq, Jukka S. Moilanen, Sanne Traasdahl Møller, Stephanie Moortgat, Daniela T. Pilz, Kate Pope, Susan Price, Alessandra Renieri, Joaquim Sá, Jeroen Schoots, Elizabeth L. Silveira, Marleen E H Simon, Anne Slavotinek, I. Karen Temple, Ineke Van Der Burgt, Bert B A De Vries, James D. Weisfeld-Adams, Margo L. Whiteford, Dagmar Wierczorek, Jan M. Wit, Connie Fung On Yee, Chandree L. Beaulieu, Sue M. White, Dennis E. Bulman, Ernie Bongers, Han Brunner, Murray Feingold, Kym M. Boycott

Research output: Contribution to journalArticle

Abstract

Background: Floating-Harbor syndrome (FHS) is a rare condition characterized by short stature, delays in expressive language, and a distinctive facial appearance. Recently, heterozygous truncating mutations in SRCAP were determined to be disease-causing. With the availability of a DNA based confirmatory test, we set forth to define the clinical features of this syndrome. Methods and results. Clinical information on fifty-two individuals with SRCAP mutations was collected using standardized questionnaires. Twenty-four males and twenty-eight females were studied with ages ranging from 2 to 52 years. The facial phenotype and expressive language impairments were defining features within the group. Height measurements were typically between minus two and minus four standard deviations, with occipitofrontal circumferences usually within the average range. Thirty-three of the subjects (63%) had at least one major anomaly requiring medical intervention. We did not observe any specific phenotype-genotype correlations. Conclusions: This large cohort of individuals with molecularly confirmed FHS has allowed us to better delineate the clinical features of this rare but classic genetic syndrome, thereby facilitating the development of management protocols.

Original languageEnglish
Article number63
JournalOrphanet Journal of Rare Diseases
Volume8
Issue number1
DOIs
Publication statusPublished - 2013

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Keywords

  • Floating Harbor syndrome
  • Phenotype
  • Short stature
  • SRCAP

ASJC Scopus subject areas

  • Medicine(all)
  • Genetics(clinical)
  • Pharmacology (medical)

Cite this

Nikkel, S. M., Dauber, A., De Munnik, S., Connolly, M., Hood, R. L., Caluseriu, O., Hurst, J., Kini, U., Nowaczyk, M. J. M., Afenjar, A., Albrecht, B., Allanson, J. E., Balestri, P., Ben-Omran, T., Brancati, F., Cordeiro, I., Da Cunha, B. S., Delaney, L. A., Destrée, A., ... Boycott, K. M. (2013). The phenotype of Floating-Harbor syndrome: Clinical characterization of 52 individuals with mutations in exon 34 of SRCAP. Orphanet Journal of Rare Diseases, 8(1), [63]. https://doi.org/10.1186/1750-1172-8-63