The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation

Rosella Visintin, Karen Craig, Ellen S. Hwang, Susanne Prinz, Mike Tyers, Angelika Amon

Research output: Contribution to journalArticle

575 Citations (Scopus)

Abstract

Exit from mitosis requires the inactivation of mitotic cyclin-dependent kinases (CDKs) by an unknown mechanism. We show that the Cdc14 phosphatase triggers mitotic exit by three parallel mechanisms, each of which inhibits Cdk activity. Cdc14 dephosphorylates Sic1, a Cdk inhibitor, and Swi5, a transcription factor for SIC1, and induces degradation of mitotic cyclins, likely by dephosphorylating the activator of mitotic cyclin degradation, Cdh1/Hct1. Feedback between these pathways may lead to precipitous collapse of mitotic CDK activity and help coordinate exit from mitosis.

Original languageEnglish
Pages (from-to)709-718
Number of pages10
JournalMolecular Cell
Volume2
Issue number6
Publication statusPublished - Dec 1998

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Cyclins
Cyclin-Dependent Kinases
Phosphoric Monoester Hydrolases
Mitosis
Phosphorylation
Transcription Factors

ASJC Scopus subject areas

  • Molecular Biology

Cite this

Visintin, R., Craig, K., Hwang, E. S., Prinz, S., Tyers, M., & Amon, A. (1998). The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation. Molecular Cell, 2(6), 709-718.

The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation. / Visintin, Rosella; Craig, Karen; Hwang, Ellen S.; Prinz, Susanne; Tyers, Mike; Amon, Angelika.

In: Molecular Cell, Vol. 2, No. 6, 12.1998, p. 709-718.

Research output: Contribution to journalArticle

Visintin, R, Craig, K, Hwang, ES, Prinz, S, Tyers, M & Amon, A 1998, 'The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation', Molecular Cell, vol. 2, no. 6, pp. 709-718.
Visintin, Rosella ; Craig, Karen ; Hwang, Ellen S. ; Prinz, Susanne ; Tyers, Mike ; Amon, Angelika. / The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation. In: Molecular Cell. 1998 ; Vol. 2, No. 6. pp. 709-718.
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