The physiology of membrane transport and endomembrane-based signalling

Michele Sallese, Teodoro Pulvirenti, Alberto Luini

Research output: Contribution to journalArticlepeer-review

Abstract

Some of the important open questions concerning the physiology of the secretory pathway relate to its homeostasis. Secretion involves a number of separate compartments for which their transport activities should be precisely cross-coordinated to avoid gross imbalances in the trafficking system. Moreover, the membrane fluxes across these compartments should be able to adapt to environmental 'requests' and to respond to extracellular signals. How is this regulation effected? Here, we consider evidence that endomembrane-based signalling cascades that are similar in organization to those used at the plasma membrane coordinate membrane traffic. If this is the case, this would also represent a model for a more general inter-organelle signalling network for functionally interconnecting different intracellular activities, a necessity for the maintenance of cellular homeostasis and to express harmonic global cellular responses.

Original languageEnglish
Pages (from-to)2663-2673
Number of pages11
JournalEMBO Journal
Volume25
Issue number12
DOIs
Publication statusPublished - Jun 21 2006

Keywords

  • Golgi
  • Membrane transport
  • Signalling

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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