The pilot European Alzheimer's Disease Neuroimaging Initiative of the European Alzheimer's Disease Consortium

Giovanni B. Frisoni, Wouter J P Henneman, Michael W. Weiner, Philip Scheltens, Bruno Vellas, Emma Reynish, Jaroslava Hudecova, Harald Hampel, Katharina Burger, Kaj Blennow, Gunhild Waldemar, Peter Johannsen, Lars Olof Wahlund, Giancarlo Zito, Paolo M. Rossini, Bengt Winblad, Frederik Barkhof

Research output: Contribution to journalArticlepeer-review

Abstract

Background: In North America, the Alzheimer's Disease Neuroimaging Initiative (ADNI) has established a platform to track the brain changes of Alzheimer's disease. A pilot study has been carried out in Europe to test the feasibility of the adoption of the ADNI platform (pilot E-ADNI). Methods: Seven academic sites of the European Alzheimer's Disease Consortium (EADC) enrolled 19 patients with mild cognitive impairment (MCI), 22 with AD, and 18 older healthy persons by using the ADNI clinical and neuropsychological battery. ADNI compliant magnetic resonance imaging (MRI) scans, cerebrospinal fluid, and blood samples were shipped to central repositories. Medial temporal atrophy (MTA) and white matter hyperintensities (WMH) were assessed by a single rater by using visual rating scales. Results: Recruitment rate was 3.5 subjects per month per site. The cognitive, behavioral, and neuropsychological features of the European subjects were very similar to their U.S. counterparts. Three-dimensional T1-weighted MRI sequences were successfully performed on all subjects, and cerebrospinal fluid samples were obtained from 77%, 68%, and 83% of AD patients, MCI patients, and controls, respectively. Mean MTA score showed a significant increase from controls (left, right: 0.4, 0.3) to MCI patients (0.9, 0.8) to AD patients (2.3, 2.0), whereas mean WMH score did not differ among the three diagnostic groups (between 0.7 and 0.9). The distribution of both MRI markers was comparable to matched US-ADNI subjects. Conclusions: Academic EADC centers can adopt the ADNI platform to enroll MCI and AD patients and older controls with global cognitive and structural imaging features remarkably similar to those of the US-ADNI.

Original languageEnglish
Pages (from-to)255-264
Number of pages10
JournalAlzheimer's and Dementia
Volume4
Issue number4
DOIs
Publication statusPublished - Jul 2008

Keywords

  • ADNI
  • Alzheimer's disease
  • CSF
  • EADC
  • Imaging
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Health Policy
  • Epidemiology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience
  • Clinical Neurology

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