The plasma membrane Na+/Ca2+ exchanger is cleaved by distinct protease families in neuronal cell death

Daniele Bano, E. Munarriz, H. L. Chen, E. Ziviani, G. Lippi, K. W. Young, P. Nicotera

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Neurodegenerative conditions commonly involve loss of neuronal connectivity, synaptic dysfunction with excessive pruning, and ionic imbalances. These often serve as a prelude to cell death either through the activation of apoptotic or necrotic death routines or excess autophagy. In many instances, a local or generalized Ca2+ deregulation is involved in signaling or executing cell death. We have recently shown that in brain ischemia, and during excitotoxicity triggered by excess glutamate, the irreversible Ca2+ deregulation leading to necrosis is due to calpain-mediated modulation of the plasma membrane Na+/Ca2+ exchanger (NCX). Here we show that the NCX can also be cleaved by caspases in neurons undergoing apoptosis, which suggests that cleavage of the main Ca2+ extrusion pathway is a lethal event in multiple forms of cell death.

Original languageEnglish
Title of host publicationSodium-Calcium Exchange and the Plasma Membrane Ca2+ATPase in Ce;; Funcyion: Fifth International Conference
Pages451-455
Number of pages5
Volume1099
DOIs
Publication statusPublished - Mar 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1099
ISSN (Print)00778923
ISSN (Electronic)17496632

Keywords

  • Brain ischemia
  • Calcium
  • Calpains
  • Caspase
  • Cell death
  • Excitotoxicity
  • NCX

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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