The plasticity of γδ T cells: Innate immunity, antigen presentation and new immunotherapy

Rita Casetti, Angelo Martino

Research output: Contribution to journalArticlepeer-review

Abstract

Several signals influence dendritic cell (DC) functions and consequent the immune responses to infectious pathogens. Our recent findings provide a new model of intervention on DCs implicating human γδ T cell stimuli. Vγ9V2 T cells represent the major subset of circulating human γδ T cells and can be activated by non-peptidic molecules derived from different microorganisms or abnormal metabolic routes. With activated-Vγ9V2 T cell co-culture, immature DCs acquire features of mature DCs, such as increasing the migratory activity, up-regulating the chemokine receptors, and triggering the Th1 immune response. Similar to the NK-derived signals, DC activation is mediated by soluble factors as well as cell-to-cell contact. Many non-peptidic molecules including nitrogen-containing bisphosphonates and pyrophosphomonoester drugs, can stimulate the activity of Vγ9V2 T cells in vitro and in vivo. The relatively low in vivo toxicity of many of these drugs makes possible novel vaccine and immune-based strategies against infectious diseases.

Original languageEnglish
Pages (from-to)161-170
Number of pages10
JournalCellular and Molecular Immunology
Volume5
Issue number3
DOIs
Publication statusPublished - Jun 2008

Keywords

  • dendritic cell
  • immunotherapy
  • innate immunity
  • T cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

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