The PLAT Study: a multidisciplinary study of hemostatic function and conventional risk factors in vascular disease patients

M. Cortellaro, C. Boschetti, E. Cofrancesco, C. Zanussi, M. Catalano, G. de Gaetano, L. Gabrielli, B. Lombardi, G. Specchia, L. Tavazzi, E. Tremoli, A. Della Volpe, E. Polli, G. Agrifoglio, O. Bugiani, F. Cobelli, M. B. Donati, S. Garattini, A. Libretti, P. MantegazzaC. Montemartini, R. Paoletti

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Abstract

In this paper are reported the basal results of a multidisciplinary, multicenter study designed to explore in a population with ischemic disease the relation between hemostatic variables, conventional risk factors and atherothrombotic sequelae. 953 patients ≤ 69 yrs with documented coronary, cerebral or peripheral atherosclerotic disease were studied and followed-up for 24 months. Examinations included hemostatic and lipid laboratory assays, arterial Doppler examination, cerebral computerized tomography and nuclear magnetic resonance, exercise electrocardiogram and coronary angiography. Fibrinogen (301.4 ± 71.52 mg/dl) correlated positively with antithrombin III (r = 0.27) and leukocytes (r = 0.25), negatively with HDL-cholesterol (r = 0.18) and tended to increase with smoking. Heavy smokers had higher leukocyte counts than non-smokers (8.0 ± 2.0 vs. 7.2 ± 2.1 × 103/μl), higher triglycerides (1.87 ± 1.12 vs. 1.53 ± 1.35 mmol/I) and lower HDL-cholesterol (0.93 ± 0.27 vs. 1.00 ± 0.25 mmol/I). FVII correlated positively with triglycerides (r= 0.16) and protein C (r = 0.45). vWF: Ag (145.4 ± 70.58%) ad FVII:C (139.7 ± 59.10%) were positively correlated (r = 0.44). FVIII:C correlated positively with fibrinogen (r = 0.21). Myocardial infarction survivors with associated cerebral and peripheral vascular lesions had higher FVIII:C, FVII, fibrinogen and vWF:Ag. These findings suggest that hemostatic factors may enhance and/or mediate the effects of conventional risk factors in atherothrombotic ischemic events.

Original languageEnglish
Pages (from-to)109-118
Number of pages10
JournalAtherosclerosis
Volume90
Issue number2-3
DOIs
Publication statusPublished - 1991

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Hemostatics
Vascular Diseases
Fibrinogen
HDL Cholesterol
Triglycerides
Antithrombin III
Protein C
Coronary Angiography
Leukocyte Count
Multicenter Studies
Blood Vessels
Survivors
Electrocardiography
Leukocytes
Magnetic Resonance Spectroscopy
Smoking
Myocardial Infarction
Tomography
Exercise
Lipids

Keywords

  • Extent of atherosclerosis
  • Hemostatic factors
  • Vascular risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The PLAT Study : a multidisciplinary study of hemostatic function and conventional risk factors in vascular disease patients. / Cortellaro, M.; Boschetti, C.; Cofrancesco, E.; Zanussi, C.; Catalano, M.; de Gaetano, G.; Gabrielli, L.; Lombardi, B.; Specchia, G.; Tavazzi, L.; Tremoli, E.; Della Volpe, A.; Polli, E.; Agrifoglio, G.; Bugiani, O.; Cobelli, F.; Donati, M. B.; Garattini, S.; Libretti, A.; Mantegazza, P.; Montemartini, C.; Paoletti, R.

In: Atherosclerosis, Vol. 90, No. 2-3, 1991, p. 109-118.

Research output: Contribution to journalArticle

Cortellaro, M, Boschetti, C, Cofrancesco, E, Zanussi, C, Catalano, M, de Gaetano, G, Gabrielli, L, Lombardi, B, Specchia, G, Tavazzi, L, Tremoli, E, Della Volpe, A, Polli, E, Agrifoglio, G, Bugiani, O, Cobelli, F, Donati, MB, Garattini, S, Libretti, A, Mantegazza, P, Montemartini, C & Paoletti, R 1991, 'The PLAT Study: a multidisciplinary study of hemostatic function and conventional risk factors in vascular disease patients', Atherosclerosis, vol. 90, no. 2-3, pp. 109-118. https://doi.org/10.1016/0021-9150(91)90105-C
Cortellaro, M. ; Boschetti, C. ; Cofrancesco, E. ; Zanussi, C. ; Catalano, M. ; de Gaetano, G. ; Gabrielli, L. ; Lombardi, B. ; Specchia, G. ; Tavazzi, L. ; Tremoli, E. ; Della Volpe, A. ; Polli, E. ; Agrifoglio, G. ; Bugiani, O. ; Cobelli, F. ; Donati, M. B. ; Garattini, S. ; Libretti, A. ; Mantegazza, P. ; Montemartini, C. ; Paoletti, R. / The PLAT Study : a multidisciplinary study of hemostatic function and conventional risk factors in vascular disease patients. In: Atherosclerosis. 1991 ; Vol. 90, No. 2-3. pp. 109-118.
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AU - Cortellaro, M.

AU - Boschetti, C.

AU - Cofrancesco, E.

AU - Zanussi, C.

AU - Catalano, M.

AU - de Gaetano, G.

AU - Gabrielli, L.

AU - Lombardi, B.

AU - Specchia, G.

AU - Tavazzi, L.

AU - Tremoli, E.

AU - Della Volpe, A.

AU - Polli, E.

AU - Agrifoglio, G.

AU - Bugiani, O.

AU - Cobelli, F.

AU - Donati, M. B.

AU - Garattini, S.

AU - Libretti, A.

AU - Mantegazza, P.

AU - Montemartini, C.

AU - Paoletti, R.

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N2 - In this paper are reported the basal results of a multidisciplinary, multicenter study designed to explore in a population with ischemic disease the relation between hemostatic variables, conventional risk factors and atherothrombotic sequelae. 953 patients ≤ 69 yrs with documented coronary, cerebral or peripheral atherosclerotic disease were studied and followed-up for 24 months. Examinations included hemostatic and lipid laboratory assays, arterial Doppler examination, cerebral computerized tomography and nuclear magnetic resonance, exercise electrocardiogram and coronary angiography. Fibrinogen (301.4 ± 71.52 mg/dl) correlated positively with antithrombin III (r = 0.27) and leukocytes (r = 0.25), negatively with HDL-cholesterol (r = 0.18) and tended to increase with smoking. Heavy smokers had higher leukocyte counts than non-smokers (8.0 ± 2.0 vs. 7.2 ± 2.1 × 103/μl), higher triglycerides (1.87 ± 1.12 vs. 1.53 ± 1.35 mmol/I) and lower HDL-cholesterol (0.93 ± 0.27 vs. 1.00 ± 0.25 mmol/I). FVII correlated positively with triglycerides (r= 0.16) and protein C (r = 0.45). vWF: Ag (145.4 ± 70.58%) ad FVII:C (139.7 ± 59.10%) were positively correlated (r = 0.44). FVIII:C correlated positively with fibrinogen (r = 0.21). Myocardial infarction survivors with associated cerebral and peripheral vascular lesions had higher FVIII:C, FVII, fibrinogen and vWF:Ag. These findings suggest that hemostatic factors may enhance and/or mediate the effects of conventional risk factors in atherothrombotic ischemic events.

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KW - Extent of atherosclerosis

KW - Hemostatic factors

KW - Vascular risk factors

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