The platelet endothelial cell adhesion molecule-1 (PECAM1) contributes to endothelial barrier function

Elisabetta Ferrero, Maria Elena Ferrero, Ruggero Pardi, Maria Raffaella Zocchi

Research output: Contribution to journalArticlepeer-review

Abstract

In this study we have analyzed the role of the platelet-endothelial cell adhesion molecule-1 (PECAM1) in vascular barrier function. PECAM1 is an immunoglobulin gene superfamily member expressed by endothelial cells at the cell boundaries. Macromolecule permeability assays performed on cell monolayers that express native or transfected PECAM1, indicated that the molecule participates in the establishment and maintenance of vascular barrier function in vitro. This hypothesis was confirmed by the finding that in vivo injection of the specific monoclonal antibody directed against the murine vascular PECAM1 led to a detectable leakage of hepatic and renal blood vessels.

Original languageEnglish
Pages (from-to)323-326
Number of pages4
JournalFEBS Letters
Volume374
Issue number3
DOIs
Publication statusPublished - Nov 6 1995

Keywords

  • Adhesion molecule
  • Endothelium
  • PECAM1
  • Vascular permeability

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

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