The platelet endothelial cell adhesion molecule-1 (PECAM1) contributes to endothelial barrier function

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

In this study we have analyzed the role of the platelet-endothelial cell adhesion molecule-1 (PECAM1) in vascular barrier function. PECAM1 is an immunoglobulin gene superfamily member expressed by endothelial cells at the cell boundaries. Macromolecule permeability assays performed on cell monolayers that express native or transfected PECAM1, indicated that the molecule participates in the establishment and maintenance of vascular barrier function in vitro. This hypothesis was confirmed by the finding that in vivo injection of the specific monoclonal antibody directed against the murine vascular PECAM1 led to a detectable leakage of hepatic and renal blood vessels.

Original languageEnglish
Pages (from-to)323-326
Number of pages4
JournalFEBS Letters
Volume374
Issue number3
DOIs
Publication statusPublished - Nov 6 1995

Fingerprint

CD31 Antigens
Blood Vessels
Endothelial Cells
Immunoglobulin Genes
Endothelial cells
Blood vessels
Macromolecules
Immunoglobulins
Monolayers
Permeability
Assays
Genes
Monoclonal Antibodies
Maintenance
Kidney
Injections
Molecules
Liver

Keywords

  • Adhesion molecule
  • Endothelium
  • PECAM1
  • Vascular permeability

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

Cite this

The platelet endothelial cell adhesion molecule-1 (PECAM1) contributes to endothelial barrier function. / Ferrero, Elisabetta; Ferrero, Maria Elena; Pardi, Ruggero; Zocchi, Maria Raffaella.

In: FEBS Letters, Vol. 374, No. 3, 06.11.1995, p. 323-326.

Research output: Contribution to journalArticle

@article{b0efcfd29d9a43d186c29cd9a1f9473f,
title = "The platelet endothelial cell adhesion molecule-1 (PECAM1) contributes to endothelial barrier function",
abstract = "In this study we have analyzed the role of the platelet-endothelial cell adhesion molecule-1 (PECAM1) in vascular barrier function. PECAM1 is an immunoglobulin gene superfamily member expressed by endothelial cells at the cell boundaries. Macromolecule permeability assays performed on cell monolayers that express native or transfected PECAM1, indicated that the molecule participates in the establishment and maintenance of vascular barrier function in vitro. This hypothesis was confirmed by the finding that in vivo injection of the specific monoclonal antibody directed against the murine vascular PECAM1 led to a detectable leakage of hepatic and renal blood vessels.",
keywords = "Adhesion molecule, Endothelium, PECAM1, Vascular permeability",
author = "Elisabetta Ferrero and Ferrero, {Maria Elena} and Ruggero Pardi and Zocchi, {Maria Raffaella}",
year = "1995",
month = "11",
day = "6",
doi = "10.1016/0014-5793(95)01110-Z",
language = "English",
volume = "374",
pages = "323--326",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - The platelet endothelial cell adhesion molecule-1 (PECAM1) contributes to endothelial barrier function

AU - Ferrero, Elisabetta

AU - Ferrero, Maria Elena

AU - Pardi, Ruggero

AU - Zocchi, Maria Raffaella

PY - 1995/11/6

Y1 - 1995/11/6

N2 - In this study we have analyzed the role of the platelet-endothelial cell adhesion molecule-1 (PECAM1) in vascular barrier function. PECAM1 is an immunoglobulin gene superfamily member expressed by endothelial cells at the cell boundaries. Macromolecule permeability assays performed on cell monolayers that express native or transfected PECAM1, indicated that the molecule participates in the establishment and maintenance of vascular barrier function in vitro. This hypothesis was confirmed by the finding that in vivo injection of the specific monoclonal antibody directed against the murine vascular PECAM1 led to a detectable leakage of hepatic and renal blood vessels.

AB - In this study we have analyzed the role of the platelet-endothelial cell adhesion molecule-1 (PECAM1) in vascular barrier function. PECAM1 is an immunoglobulin gene superfamily member expressed by endothelial cells at the cell boundaries. Macromolecule permeability assays performed on cell monolayers that express native or transfected PECAM1, indicated that the molecule participates in the establishment and maintenance of vascular barrier function in vitro. This hypothesis was confirmed by the finding that in vivo injection of the specific monoclonal antibody directed against the murine vascular PECAM1 led to a detectable leakage of hepatic and renal blood vessels.

KW - Adhesion molecule

KW - Endothelium

KW - PECAM1

KW - Vascular permeability

UR - http://www.scopus.com/inward/record.url?scp=0028811546&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028811546&partnerID=8YFLogxK

U2 - 10.1016/0014-5793(95)01110-Z

DO - 10.1016/0014-5793(95)01110-Z

M3 - Article

C2 - 7589563

AN - SCOPUS:0028811546

VL - 374

SP - 323

EP - 326

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 3

ER -