The PNPLA3 I148M variant and chronic liver disease: When a genetic mutation meets nutrients

Cristina Maglio; Carlo Pirazzi; Arturo Pujia; Luca Valenti; Stefano Romeo

doi:10.1016/j.foodres.2014.01.055

The PNPLA3 I148M variant and chronic liver disease: When a genetic mutation meets nutrients

Cristina Maglio, Carlo Pirazzi, Arturo Pujia, Luca Valenti, Stefano Romeo

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

The isoleucine to methionine substitution at position 148 in the patatin-like phospholipase domain containing 3 protein (PNPLA3; I148M variant, rs738409) is associated with liver fat accumulation and an increased risk of chronic liver disease ranging from hepatitis to hepatocellular carcinoma. This review discusses the interaction between the PNPLA3 I148M variant and obesity/intake of specific nutrients in determining the susceptibility to liver disease. We present the results of several studies showing that obesity or alcohol abuse enhances the effect of the PNPLA3 I148M variant on the liver. We also show that specific nutrients interact with the PNPLA3 I148M variant in modulating liver disease susceptibility.

Original language	English
Pages (from-to)	239-243
Number of pages	5
Journal	Food Research International
Volume	63
DOIs	https://doi.org/10.1016/j.foodres.2014.01.055
Publication status	Published - 2014

Keywords

Adiponutrin
Liver steatosis
Nutrigenetics
Obesity
PNPLA3 rs738409

ASJC Scopus subject areas

Food Science

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title = "The PNPLA3 I148M variant and chronic liver disease: When a genetic mutation meets nutrients",

abstract = "The isoleucine to methionine substitution at position 148 in the patatin-like phospholipase domain containing 3 protein (PNPLA3; I148M variant, rs738409) is associated with liver fat accumulation and an increased risk of chronic liver disease ranging from hepatitis to hepatocellular carcinoma. This review discusses the interaction between the PNPLA3 I148M variant and obesity/intake of specific nutrients in determining the susceptibility to liver disease. We present the results of several studies showing that obesity or alcohol abuse enhances the effect of the PNPLA3 I148M variant on the liver. We also show that specific nutrients interact with the PNPLA3 I148M variant in modulating liver disease susceptibility.",

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AU - Maglio, Cristina

AU - Pirazzi, Carlo

AU - Pujia, Arturo

AU - Valenti, Luca

AU - Romeo, Stefano

PY - 2014

Y1 - 2014

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AB - The isoleucine to methionine substitution at position 148 in the patatin-like phospholipase domain containing 3 protein (PNPLA3; I148M variant, rs738409) is associated with liver fat accumulation and an increased risk of chronic liver disease ranging from hepatitis to hepatocellular carcinoma. This review discusses the interaction between the PNPLA3 I148M variant and obesity/intake of specific nutrients in determining the susceptibility to liver disease. We present the results of several studies showing that obesity or alcohol abuse enhances the effect of the PNPLA3 I148M variant on the liver. We also show that specific nutrients interact with the PNPLA3 I148M variant in modulating liver disease susceptibility.

KW - Adiponutrin

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KW - Nutrigenetics

KW - Obesity

KW - PNPLA3 rs738409

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The PNPLA3 I148M variant and chronic liver disease: When a genetic mutation meets nutrients

Abstract

Keywords

ASJC Scopus subject areas

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