The POEMS syndrome: Report of six cases

D. Pareyson, R. Marazzi, P. Confalonieri, G. L. Mancardi, A. Schenone, A. Sghirlanzoni

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We report six patients affected by POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, and Skin changes), a peculiar multiorgan disease frequently associated with osteosclerotic myeloma or other plasma cell disorders. Sensorimotor polyneuropathy was associated with multisystem involvement in all of the patients, with osteosclerotic myeloma in 2 cases, monoclonal gammopathy of undetermined significance in 2 cases and Castleman's disease in the final two. In all of the patients, sural nerve biopsy findings were consistent with a mixed, axonal and demyelinating neuropathy. Increased levels of Interleukin-6 were found in two cases, but the pathogenesis of the disease is far from established.

Original languageEnglish
Pages (from-to)353-358
Number of pages6
JournalItalian Journal of Neurological Sciences
Volume15
Issue number7
DOIs
Publication statusPublished - Jul 1994

Fingerprint

POEMS Syndrome
Monoclonal Gammopathy of Undetermined Significance
Giant Lymph Node Hyperplasia
Sural Nerve
Paraproteinemias
Polyneuropathies
Plasma Cells
Interleukin-6
Biopsy
Skin

Keywords

  • Castleman's disease
  • cytokines
  • monoclonal gammopathy
  • osteosclerotic myeloma
  • POEMS syndrome
  • polyneuropathy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

The POEMS syndrome : Report of six cases. / Pareyson, D.; Marazzi, R.; Confalonieri, P.; Mancardi, G. L.; Schenone, A.; Sghirlanzoni, A.

In: Italian Journal of Neurological Sciences, Vol. 15, No. 7, 07.1994, p. 353-358.

Research output: Contribution to journalArticle

Pareyson, D, Marazzi, R, Confalonieri, P, Mancardi, GL, Schenone, A & Sghirlanzoni, A 1994, 'The POEMS syndrome: Report of six cases', Italian Journal of Neurological Sciences, vol. 15, no. 7, pp. 353-358. https://doi.org/10.1007/BF02339932
Pareyson, D. ; Marazzi, R. ; Confalonieri, P. ; Mancardi, G. L. ; Schenone, A. ; Sghirlanzoni, A. / The POEMS syndrome : Report of six cases. In: Italian Journal of Neurological Sciences. 1994 ; Vol. 15, No. 7. pp. 353-358.
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