The POEMS syndrome: Report of six cases

D. Pareyson, R. Marazzi, P. Confalonieri, G. L. Mancardi, A. Schenone, A. Sghirlanzoni

Research output: Contribution to journalArticle


We report six patients affected by POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, and Skin changes), a peculiar multiorgan disease frequently associated with osteosclerotic myeloma or other plasma cell disorders. Sensorimotor polyneuropathy was associated with multisystem involvement in all of the patients, with osteosclerotic myeloma in 2 cases, monoclonal gammopathy of undetermined significance in 2 cases and Castleman's disease in the final two. In all of the patients, sural nerve biopsy findings were consistent with a mixed, axonal and demyelinating neuropathy. Increased levels of Interleukin-6 were found in two cases, but the pathogenesis of the disease is far from established.

Original languageEnglish
Pages (from-to)353-358
Number of pages6
JournalItalian Journal of Neurological Sciences
Issue number7
Publication statusPublished - Jul 1994


  • Castleman's disease
  • cytokines
  • monoclonal gammopathy
  • osteosclerotic myeloma
  • POEMS syndrome
  • polyneuropathy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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