The polymorphonuclear neutrophil (PMN) immunohistological technique: Detection of immune complexes bound to the PMN membrane in acute poststreptococcal and lupus nephritis

G. Camussi, F. C. Cappio, M. Messina, R. Coppo, P. Stratta, A. Vercellone

Research output: Contribution to journalArticlepeer-review

Abstract

Twenty-nine patients with Systemic Lupus Erythematosus (SLE) and 6 patients with Acute Poststreptococcal Glomerulonephritis (APGN) have been studied with the polymorphonuclear neutrophil (PMN) immunohistological technique to detect in vivo interaction between circulating immune complexes (IC) and PMN membrane receptors. Patients have been studied both at diagnosis and during follow-up and the results compared to those yielded by the C1qSP test. Our data provide evidence that the PMN immunohistological technique may prove a useful tool in monitoring IC disease. Moreover, elution studies may allow the detection and characterization of the antigens in the OMN-bound IC.

Original languageEnglish
Pages (from-to)280-287
Number of pages8
JournalClinical Nephrology
Volume14
Issue number6
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Nephrology

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